山石榴中木脂素类成分研究  

Study on Lignans from Catunaregam spinosa

作　　者：高广春[1,2] 陶曙红[3] 张偲[2] 李庆欣[2] 

机构地区：[1]浙江省农业科学院植物保护与微生物研究所,杭州310021 [2]中国科学院南海海洋研究所,广东省海洋药物重点实验室,广州510301 [3]广东药学院,广州510006

出　　处：《中国药学杂志》2010年第9期650-653,共4页Chinese Pharmaceutical Journal

基　　金：中国科学院重要方向性项目(KZCX2-YW-216)

摘　　要：目的研究红树伴生植物山石榴(Catunaregam spinosa Tirveng)的化学成分。方法采用各种现代色谱技术进行分离纯化,根据化合物的波谱数据进行结构鉴定。结果从山石榴地上部分的乙酸乙酯萃取物中分离得到12个木脂素类化合物,分别为erythro-guaiacylglycerol-β-coniferyl ether(Ⅰ),threo-guaiacylglycerol-β-coniferyl ether(Ⅱ),erythro-guaiacylglycerol-β-coniferylaldehyde ether(Ⅲ),threo-guaiacylglycerol-β-coniferyl aldehyde ether(Ⅳ),erythro-guaiacylglycerol-β-ferulic acid ether(Ⅴ),threo-guaiacylglycerol-β-ferulic acid ether(Ⅵ),异落叶松脂醇(isolariciresinol,Ⅶ),lyoniresinol(Ⅷ),5′-甲氧基异落叶松脂醇(5′-me-thoxyisolariciresinol,Ⅸ),(7R,8S)ficusal(Ⅹ),balanophonin(Ⅺ)和5″-methoxy-4″-O-(8-guaiacylglycerol)buddlenol A(Ⅻ)。结论12个木脂素类化合物均为首次从该属植物中分离得到。OBJECTIVE To investigate the chemical constituents of mangrove associated Catunaregam spinosa.METHODS The compounds were isolated and purified by various modern chromatography techniques and their structures were elucidated by spectral analysis.RESULTS Twelve lignan compounds were obtained from the stem bark of Chinese mangrove associate C.spinosa.and elucidated as erythro-guaiacylglycerol-β-coniferyl ether（Ⅰ）,threo-guaiacylglycerol-β-coniferyl ether（Ⅱ）,erythro-guaiacylglycerol-β-coniferyl aldehyde ether（Ⅲ）,threo-guaiacylglycerol-β-coniferyl aldehyde ether（Ⅳ）,erythro-guaiacylglycerol-β-ferulic acid ether（Ⅴ）,threo-guaiacylglycerol-β-ferulic acid ether（Ⅵ）,isolariciresinol（Ⅶ）,lyoniresinol（Ⅷ）,5′-methoxyisolariciresinol（Ⅸ）,（7R,8S） ficusal（Ⅹ）,balanophonin（Ⅺ） and 5″-methoxy-4″-O-（8-guaiacylglycerol） buddlenol A（Ⅻ）.CONCLUSION Twelve compounds were all obtained from Catunaregam genus for the first time.

关 键 词：山石榴 化学成分 红树伴生植物 木脂素 

分 类 号：R284[医药卫生—中药学]