CFH Y402H基因多态性与冠状动脉粥样硬化性心脏病的相关性研究——附101例报告  

Association of Y402H polymorphism in the complement factor H gene and coronary atherosclerotic heart disease

作　　者：崔芬[1] 杨志寅[2] 

机构地区：[1]山东大学医学院,250012 [2]山东济宁医学院,272073

出　　处：《新医学》2010年第4期237-240,共4页Journal of New Medicine

基　　金：山东省教育厅科技计划项目(J08LG06)

摘　　要：目的:探讨补体因子H(CFH)基因Y402H多态性与冠状动脉粥样硬化性心脏病(冠心病)的相关性。方法:选择冠心病患者101例、非冠心病对照组50例,采用聚合酶链反应-限制性片段长度多态性分析(PCR-RFLP)技术,分析CFH基因Y402H多态性在两组的分布频率并进行比较。结果:冠心病组吸烟、高血压比例明显高于对照组(P<0.01)。冠心病组与对照组CFH基因Y402H中TT、TC、CC基因型频率分布差异无统计学意义(P>0.05)。结论:CFH基因Y402H多态性可能与冠心病无相关性。Objective：To investigate the association between Y402H polymorphism in the complement factor H gene（CFH） and coronary atherosclerotic heart disease（CHD）.Methods：One hundred and one patients with CHD and 50 healthy controls were enrolled.Genomic DNA from whole blood was extracted.The Y402H polymorphism in CFH was determined by polymerase chain reaction-restriction fragment length polymorphism analysis（PCR-RFLP）.Results：The proportions of patients who smoked or got hypertension in CHD group were higher than that in control group（P0.01）.There was no significant difference in the frequency distribution of CFH gene polymorphism TT,TC,CC between the two groups（P0.05）.Conclusion：No association was found between Y402H polymorphism in CFH gene and CHD.

关 键 词：补体因子H 基因多态性 危险因素 冠状动脉粥样硬化性心脏病 

分 类 号：R541.4[医药卫生—心血管疾病]