胆结石对胆囊粘膜的病理损害及其与胆囊癌关系的研究  

The Pathologic Changes in Gallbladder Mucosa Caused by Gallstone and the Relationship between Gallstone and Carcinoma

作　　者：石景森[1] 周连锁[1] 陈革[1] 卢云[1] 郝秀原[1] 刘刚[1] 韩文胜[1] 

机构地区：[1]西安医科大学第一临床医学院肝胆外科研究室,710061

出　　处：《外科理论与实践》1999年第1期31-32,共2页Journal of Surgery Concepts & Practice

摘　　要：研究结石对胆囊粘膜的病理损害及这一过程中细胞DNA和AgNOR含量的改变,以探讨各型病理改变在胆囊癌发病中的作用。方法:对165例连续切除的胆囊标本进行病理及组化研究。结果:合并结石时胆囊粘膜的单纯增生、不典型增生、胆囊癌发生率分别为75.2％、19.33％和5.4％;结石引起的化生率为38.8％;胆囊粘膜从单纯增生到轻、中、重度不典型增生及胆囊癌的AgNOR颗粒及面积与DNA倍体含量逐步增高;50岁以上结石患者的化生、不典型增生、DNA及AgNOR含量均明显增加。结论:胆囊结石病例的不典型增生明显增多,推测不典型增生是胆囊癌的重要癌前病变,50岁以上的结石患者胆囊癌风险明显增加。To study the pathologic changes in the mucosa of gallbladder mucosa containing stone(s), we determined its DNA and AgNOR protein contents and discuss the role played by the pathologic le-sions in inducing carcinoma. Methods: Histochemical studies were made in 156 cases of gallstones and 9 cases of gallbladder carcinoma with stone(s). Results: The rate of hyperplasia, dysplasia and carcinoma of the gallbladder mucosa were 75.2%, 19.33% and 5.46% respectively. The metaplasia rate of gallbladder mucosa was 38.8%. Conclusions: The DNA and AgNOR protein contents increased from hyperplasia, dys-plasia to carcinoma. The rate of dysplasia and metaplasia as well as the DNA and AgNOR protein cont-ents increased greatly in patients over 50.

关 键 词：胆结石 病理 胆囊癌 胆囊粘膜 

分 类 号：R657.420.2[医药卫生—外科学] R735.802[医药卫生—临床医学]