正常孕妇及妊高征患者血浆中5-羟色胺和5-羟吲哚乙酸含量的测定  

The Change of Serotonin and 5 hydroxyindole Acetate of Venous Blood in Normal Pregnancy Women and in Women with Pregnancy Induced Hypertension

作　　者：任东平[1] 杨琳[1] 殷建清[1] 任琳[1] 杨梦庚[2] 张汉霆[3] 

机构地区：[1]空军总医院妇产科,北京100036 [2]西安第四军医大学唐都医院妇产科 [3]军事医学科学院药理毒理研究所

出　　处：《中华围产医学杂志》1999年第1期6-7,共2页Chinese Journal of Perinatal Medicine

摘　　要：目的　探讨血浆中５羟色胺（５ＨＴ） 和５羟吲哚乙酸（５ＨＩＡＡ） 与妊高征发病的关系。　方法　采用高效液相色谱—电化学检测法测定正常妊娠各期孕妇组及妊高征组血浆中５ＨＴ和５ＨＩＡＡ含量。　结果　正常妊娠各期孕妇组血浆中５ＨＴ含量无显著差异；妊高征组血浆中５ＨＴ含量（７０－４４ ±２８－６９ μｇ／Ｌ）明显高于正常晚孕组（２４－９６±６－５７ μｇ／Ｌ）（ Ｐ＜ ０．０１） ；妊高征组血浆中５ＨＩＡＡ 含量（４－１１±２．３０ μｇ／Ｌ） 较正常晚孕组（７－８７ ±１．７５ μｇ／Ｌ） 明显降低，Ｐ＜ ０．０１。　结论　孕妇血浆中５ＨＴ含量变化可能与妊高征血管收缩的病理过程有关。Objective To provide evidence for the hypothesis that the involvement of serotonin(5 HT) and 5 hydroxyindole acetate(5 HIAA) takes part in the pathogenesis of pregnancy induced hypertension(PIH). Methods Patients with PIH and normal pregnant woman were studied.5 HT and 5 HIAA in plasma from all subjects were measured with high performance liquid chromatography and electrochemical detection. Results There was no difference with 5 HT in plasma in three trimesters( P > 0.05 ).The concentration of 5 HT in plasma of PIH group(70 44±28 69 μg/L) was higher than that in normal group(24 96±6 57 μg/L)( P <0.01).The concentration of 5 HIAA in plasma of PIH group(4 11±2.30 μg/L) was less than that in normal group(7 87±1.75μg/L)( P <0.01). Conclusion 5 HT in plasma is related to the blood pressure of pregnancy woman;5 HT in plasma may take part in the pathophysiologic changes of PIH.

关 键 词：妊娠高血压 综合征 血清素 羟基吲哚乙酸 病理 

分 类 号：R714.246[医药卫生—妇产科学]