β-葡萄糖醛酸苷酶测定对新生儿母乳性黄疸的诊断价值  

Diagnostic Values of β glucuronidase Measurement for Breast Milk Jaundice in Neonates

作　　者：周晓光[1] 杨杰[1] 杨琳琳[1] 吴婕翎 

机构地区：[1]广东省妇幼保健院新生儿科,广州510010 [2]广东省新生儿护理抢救中心

出　　处：《中华围产医学杂志》1999年第1期39-41,共3页Chinese Journal of Perinatal Medicine

摘　　要：目的　探讨β葡萄糖醛酸苷酶（βＧＤ） 与母乳性黄疸的关系，以及母乳和粪便βＧＤ 测定在母乳性黄疸诊断上的意义。　方法　采用酶学比色法对４７ 例母乳性黄疸及６０ 例正常新生儿母乳及粪便βＧＤ活性浓度进行测定，并分析母乳及粪便βＧＤ活性浓度测定在母乳性黄疸患儿的阳性率。　结果　黄疸组母乳及粪便βＧＤ活性浓度（１－３６３ ±０ ．２９９ Ｕ／Ｌ 及１－０７１ ±０ ．２９７ Ｕ／Ｌ） 较正常组（０．７４６ ±０ ．３２５ Ｕ／Ｌ及０ ．４９６ ±０ ．２７６ Ｕ／Ｌ） 明显增高，两组之间具有极显著差异（Ｐ＜ ０．００１）。两组母乳βＧＤ测定的阳性率分别为６６－０ ％ 与８－３ ％ ，差异有显著性意义（ Ｐ＜ ０ ．０１） 。其灵敏度、特异度、阳性预测值、阴性预测值及诊断正确率分别为６６－０％ 、９１－７ ％ 、８６－１％ 、７７－５ ％ 及８０－４ ％ 。两组粪便βＧＤ测定的阳性率分别为６８－１ ％ 与６－７％ ，差异有显著性意义（ Ｐ＜０ ．０１）。其灵敏度、特异度、阳性预测值、阴性预测值及诊断正确率分别为６８－１％ 、９３－３％ 、８８－９％ 、７８－９％ 及８２－２ ％ 。　结论　βＧＤ活性浓度与母乳性黄疸的发生、发展密切相关，母乳与粪?Objective To study the relationship between β glucuronidase(β GD) and breast milk jaundice and the diagnostic vaules of breast milk and fecal β GD measurement for breast milk jaundice in neonates. Methods Milk and fecal β GD activities were measured in 47 newborns with breast milk jaundice and in 60 healthy newborns by using enzymological method.The positive rates of milk and fecal β GD measurement in babies with breast milk jaundice were analysed. Results Milk and fecal β GD activities (1 363±0.299 U/L and 1 071±0.297 U/L) were significantly higher in infants with breast milk jaundice than those in healthy infants (0.746±0.325 U/L and 0.496±0.276 U/L).The positive rates of milk β GD measurement in infants with breast milk jaundice and healthy newborns were 66.0% and 8.3% respectively.The difference between them was significant( P <0.01).Its sensitivity,specificity,positive predicting value,negative predicting value and correct diagnostic rate were 66.0%,91.7%,86 1%,77 5% and 80 4% respectively.The positive rates of fecal β GD measurement in babies with breast milk jaundice and healthy newborns were 68.1% and 6.7% respectively,the difference between them was significant( P <0.01).Its sensitivity,specificity,positive predicting value,negative predicting value and correct diagnostic rate were 68.1%,93 3%,88 9%,78 9% and 82.2% respectively. Conclusion β GD activity seems to be an important factor in breast milk jaundice in neonates.Milk and fecal β GD measurement may be useful for diagnosis of breast milk jaundice.

关 键 词：新生儿黄疸 葡糖醛酸酶 诊断 

分 类 号：R722.170.4[医药卫生—儿科]