理气调补汤对运动性疲劳大鼠下丘脑-垂体-肾上腺轴的影响  

Effect of Liqi Tiaobu Tang on Hypothalamic-Pituitary-Adrenal Axis in Fatigue Induced by Exercise in Rat

作　　者：王丛笑[1] 方素萍[2] 马丽华[1] 周军[1] 

机构地区：[1]首都体育学院,北京100088 [2]中国中医科学院广安门医院分子生物室,北京100053

出　　处：《中国实验方剂学杂志》2010年第5期139-141,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：北京市教育委员会人才强教项目资助课题(PXM2008-014206-053361)

摘　　要：目的:探讨理气调补汤对运动性疲劳大鼠下丘脑-垂体-肾上腺轴的调节作用。方法:30只健康雄性SD大鼠随机分为3组。采用大鼠游泳运动训练方式,观察大鼠最后1次力竭游泳的力竭时间、血清皮质酮、睾酮、血清和下丘脑β内啡肽含量等指标。结果:理气调补汤可以延长大鼠游泳力竭的时间(P<0.01),提高血清睾酮含量;降低血清β内啡肽含量。结论:理气调补汤可以改善运动性疲劳大鼠下丘脑-垂体-肾上腺轴的功能,从而起到预防运动性疲劳的作用。Objective：To observe and to discuss the effect of Liqi Tiaobu Tang on hypothalamic-pituitaryadrenal axis in the rat of fatigue induced by exercise. Method：30 male SD rats were randomly divided into 3 groups. Ⅰ and Ⅱ groups are all trained for 6 weeks with swimming. The last exhaustive swimming time,serum corticosterone,testosterone,and hypothalamic β-endorphin were observed. Result：Liqi Tiaobu Tang could extend the time for exhaustive swimming in rats（P 0. 01）,increase the content of T,and decrease the content of serum β-endorphin. Conclusion：Liqi Tiaobu Tang improves hypothalamus-pituitary-adrenal axis function in the rat of fatigue induced by exercise. It may prevent the exercise fatigue.

关 键 词：理气调补汤 运动性疲劳 下丘脑-垂体-肾上腺轴 

分 类 号：R285.5[医药卫生—中药学]