神昌注射液对脑栓塞大鼠血小板活化和血栓形成的影响  

Effects of Shenchang Injection on Platelet Activation and Thrombosis in MCAO Rats

作　　者：李翎[1] 方永奇[1] 邹衍衍[1] 林双峰[1] 王丽新[1] 李小兵[1] 何玉萍[1] 

机构地区：[1]广州中医药大学第一附属医院,广州510405

出　　处：《中国实验方剂学杂志》2010年第5期175-177,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广东省科技厅攻关课题(2003C34403)

摘　　要：目的:观察神昌注射液对脑栓塞大鼠血小板活化和血栓形成的影响。方法:造大鼠大脑中动脉脑栓塞(MCAO)模型,静脉给药7次后,取血,用流式细胞仪测CD62P、CD63;并观察肾静脉血栓形成及凝血时间。结果:神昌注射液能降低脑缺血大鼠血液的CD62P、CD63表达率,降低大鼠下腔肾静脉血栓的重量,延长小鼠的凝血时间。结论:神昌注射液能降低血小板活化功能,减轻静脉血栓的形成,延缓血液凝固,是其治疗中风的药理学基础。Objective：To observe effects of Shenchang Injection on platelet activation and thrombosis in MCAO rats. Method： The cerebral injury model induced by ischemia /reperfusion was made in rat by MCAO. Shenchang injection was given by iv for 7 times,then CD62p、CD63 were measured by flow-cytometry. Thrombosis and clotting time were observed. Result：Shenchang injection could decrease expression of CD62p and CD63 in blood,decline thrombosis in kidney vein,delay clotting time in MCAO rats. Conclusion：Shenchang injection is effect for antiplatelet activities and postponement of thrombosis by extending blood clotting. These are likely the pharmacological basis of the injection for treating stroke.

关 键 词：神昌注射液 石菖蒲 冰片 脑栓塞 血小板活化 

分 类 号：R285.5[医药卫生—中药学]