普胃丸对复发胃溃疡大鼠抗氧化及改善胃黏膜血流的作用  

Effect of Puwei Pill on Anti-oxidation and Improvement of Gastric Mucosal Blood Flow in Rats with Gastric Ulcer Recurrence

作　　者：贾欣[1] 冯永[1] 耿菲[1] 吕华[1] 刘淑梅[1] 白静[1] 齐亚娟[1] 

机构地区：[1]华北煤炭医学院药理教研室,河北唐山063000

出　　处：《中国实验方剂学杂志》2010年第5期183-186,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河北省唐山市科学技术研究与发展计划课题(08360202A-3)

摘　　要：目的:研究普胃丸(PWP)对复发胃溃疡大鼠抗氧化及改善胃黏膜血流的作用。方法:采用白细胞介素1β(IL-1β)制备大鼠胃溃疡复发模型,观察连续igPWP90d胃组织病理学变化,测定血浆中超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)、内皮素-1(ET-1)及胃黏膜组织ET-1A的表达。结果:PWP能明显降低溃疡复发率,增加血浆SOD、NO活性,减少MDA、ET-1含量,显著抑制复发胃溃疡胃黏膜组织中ET-1A的表达。结论:PWP可抑制胃溃疡复发,其机制与增强机体抗氧化及改善黏膜血流量有关。Objective：To study the effect of Puwei Pill（PWP） on the anti-oxidation and improvement of the gastric mucosal blood flow in the rats with gastric ulcer recurrence. Method：The gastric ulcer recurrence model was developed by intraperitoneal injection with interleukin-1β （ IL-1β ）. Then the pathohistological structure in the recurred gastric ulcer,treated by PWP （ ig,90 d）,was observed. The superoxide dismutase （ SOD）,nitric oxide （NO）,malondialdehyde（MDA） and endothelin-1 （ET-1） in the plasma and ET-1A expressed in the gastric mucosa were determined. Result： PWP could significantly resist the recurrence of gastric ulcer,increase the SOD,NO activity and decrease the contents of MDA and ET-1 in plasma. At the same time,PWP could significantly inhibit the ET-1A expression in the gastric mucosa. Conclusion：PWP can prevent the recurrence of the gastric ulcer, which mechanism is probably related to the increase of anti-oxidation capacity and improvement of mucosal blood flow.

关 键 词：胃溃疡 复发 普胃丸 抗氧化 血流量 

分 类 号：R285.5[医药卫生—中药学]