高血压患者脉搏波速度的变化及琥珀酸美托乐尔缓释片干预的影响  

Effects of metoprolol succinate sustained-release tablets on pulse wave velocity in patients with essential hypertension

作　　者：刘恒亮[1] 刘洋[1] 耿国英[1] 毛磊[1] 吴雷[1] 刘灵芝[1] 

机构地区：[1]河南省郑州人民医院心内科,450002

出　　处：《中国临床实用医学》2010年第5期1-3,共3页China Clinical Practical Medicine

基　　金：河南省郑州市科技立项（项目编号：083SGYS33238-2）

摘　　要：目的探讨琥珀酸美托乐尔缓释片对高血压患者脉搏波速度的影响。方法28例首次确诊的高血压患者与28例正常对照组对比分析血压、血糖、血脂和脉搏波速度，琥珀酸美托乐尔缓释片治疗12周后重复测量上述指标，前后对比分析血压和脉搏波速度的变化。结果高血压患者收缩压（156．3±8．6）mmHg比（112．6±11．9mmHg、舒张压（103．6±6．7）mmHg比（68．2±8．9）mmHg和脉搏波速度（1971．3±187．4）cm／s比（1187．2±198．5）cm／s显著高于正常对照组（P〈0．05）。琥珀酸美托乐尔缓释片治疗12周后，患者心率（85．2±4．7）比（64．5±6．3）收缩压（156．3±8．6）mmHg比（121．9±7．9）mmHg、舒张压（103．6±6．7）mmHg比（76．3±5．1）mmHg和脉搏波速度（1971．3±187．4）cm／s比（1236．5±186．3）cm／s）显著下降（P〈0．05）。结论琥珀酸美托乐尔缓释片可以降低高血压患者的脉搏波速度，改善动脉顺应性。Objective To evaluate the effects of metoprolol succinate sustained-release tablets on Bra- ehial-ankle pulse wave velocity （baPWV）in patients with essential hypertension. Methods The levels of serum blood lipid and blood glucose, blood pressure, heart rate and baPWV were measured respectively in twenty-eight patients with essential hypertension and twenty-eight healthy persons with normal blood pressure. After twelve weeks treated with metoprolol succinate sustained-release tablets ,The blood pressure and baPWV were measured again and were studied in patients with essential hypertension. Results The systolic blood pressure（ 156. 3 ± 8.6） mm Hg vs（ 112. 6 ±11.9 ）mm Hg, diastolic blood pressure （103.6 ±6. 7 ）into Hg vs（68.2 ±8.9 ）mm Hg and baPWV（ 1971.3 ± 187.4 ） cm/s vs （ 1187.2 ± 198.5 ） cm/s in patients with essential hypertension were higher than that of healthy persons with normal blood pressure significantly（ P 〈 0.05 ）, The heart rate （85.2 ± 4. 7）vs（64. 5 ± 6. 3 ） beat/rain, systolic blood pressure（ 156.3 ± 8.6）mm Hg vs（ 121.9 ± 7.9 ）mm Hg, dias- tolic blood pressure（ 103.6 ± 6. 7 ） nun Hg vs （ 76. 3 ± 5.1 ） mm Hg and baPWV （ 1971.3 ± 187.4 ） cm/s vs （1236. 5 ±186. 3 ）cm/s were decreased significantly in patients with essential hypertension（ P 〈 0. 05 ）after treated with metoprolol suceinate sustained-release tablets. Conclusion Metoprolol sueeinate sustained-release tablets treated in patients with essential hypertension can decreased pulse wave velocity, impore elasticity of large arterise and increase the distensibility of aorta.

关 键 词：高血压 脉搏波速度 琥珀酸美托乐尔缓释片 

分 类 号：R544[医药卫生—心血管疾病]