芦荟汁对烫伤大鼠皮肤的愈合及SOD、MDA及GSH-PX的影响  

The effects of aloe juice on SOD, GSH-PX , MDA and skin wound healing in scalded rats

作　　者：叶俊毅[1] 朱佳荣[1] 王力[1] 涂寅[1] 姚富黎[1] 万克英[1] 

机构地区：[1]咸宁学院临床医学院皮肤科,湖北省咸宁437100

出　　处：《中国医师杂志》2010年第4期459-461,共3页Journal of Chinese Physician

摘　　要：目的 观察芦荟汁对烫伤大鼠的皮肤愈合及体内氧自由基清除的影响.方法 将24只大鼠分为3组,即芦荟组、烧伤膏组,空白组;分别在大鼠背部造成直径为2.6 cm的深Ⅱ度烫伤创面,涂烧伤膏、芦荟汁,观察上皮出现时间及愈合时间,并检测愈合面的皮肤SOD、GSH-PX、MDA含量.结果 芦荟组上皮出现时间（4.6±0.56）d,愈合时间（16.2±2.6）,烧伤膏组上皮出现时间（5.4±0.6）d,愈合时间（18.1±3.4）d,空白组上皮出现时间（6.8±0.3）d,愈合时间（22.3±3.2）d.芦荟组、烧伤膏组上皮出现时间和愈合时间与空白组比较差异均有统计学意义（P〈0.01）,芦荟组与烧伤膏组比较差异无统计学意义（P〉0.05）.芦荟组SOD（98.07±6.22）、GSH-PX（243.21±20.18）、MDA（4.89±2.12）,烧伤膏组SOD（83.97±6.34）、GSH-PX（208.25±24.52）、MDA（6.93±3.05）与空白组SOD（57.50±9.43）、GSH-PX（139.88±22.70）、MDA（8.98±2.14）比较差异均有统计学意义（P〈0.01）,芦荟组与烧伤膏组比较差异无统计学意义（P〉0.05）.结论 芦荟汁具有促进大鼠创面愈合、清除体内自由基而保护细胞的作用.Objective To observe the effects of aloe juice on skin wound healing in scalded rats and scavenging the oxygen free radical in their bodies. Methods 24 rats were divided into 3 groups,namely, aloe group, burn cream group and blank control group. And burn wounds （ Ⅱ degree deep） were created with a diameter of 2. 6cm in their backs, respectively. Smear Burn Ointment and Aloe Vera juice,were used to observe the time of the appearance of their epithelial tissues and the time of the wound healing,and the content of SOD, GSH-PX and MDA in healed skin surfaces were detected. Results The time of the appearance of epithelial tissues[（4.6 ±0. 56）d ,（16.2±2.6）,（5.4±0.6）d,（18. 1 ±3.4）d,（6.8± 0. 3） d , （22. 3 ± 3.2 ） d], the wound healing and the content of SOD [（ （98.07 ± 6. 22） vs（83.97 ± 6. 34）, （57. 50 ± 9. 43 ）], GSH-PX [（243.21 ± 20. 18）vs （208.25 ± 24. 52）, （ 139. 88 ± 22. 70）] and MDA [（4. 89 ±2. 12） vs （6. 93 ± 3.05 ）, （8.98 ± 2. 14）] in aloe group have significant difference compared with the blank group（ P 〈0.01, 0.001, 0.005）, but no significant difference compared with the burn cream group. Conclusion Aloe juice has the effects of promoting the skin wound healing of scalded rats ,scavenging the oxygen free radical in their bodies and protecting cells.

关 键 词：芦荟△/药理学 烧伤/药物疗法 伤口愈合/药物作用 超氧化物歧化酶/代谢/药物作用 丙二醛/代谢/药物作用 谷胱甘肽过氧化酶/代谢/药物作用 

分 类 号：R285.5[医药卫生—中药学]