聚乙二醇为分散剂制备纳米生物活性玻璃粉体  

Preparation of Nanoscale Bioactive Glasses by Addition of PEG as Surface Dispersion Agent

作　　者：张娟娟[1,2] 陈晓峰[1,2] 林才[1,3] 雷波[1,2] 李玉莉[1,2] 

机构地区：[1]华南理工大学生物医学工程研究院,广州510640 [2]教育部特种功能材料重点实验室(广州),广州510640 [3]温州医学院附属第一医院,温州325027

出　　处：《硅酸盐通报》2010年第2期257-261,共5页Bulletin of the Chinese Ceramic Society

基　　金：国家自然科学基金重点项目(50830101;50732003);国家自然科学基金项目(50672028);浙江省自然科学基金(Y407241)

摘　　要：采用溶胶-凝胶共沉淀方法结合冷冻干燥技术制备颗粒尺寸在纳米级的生物活性玻璃(NBG),研究了加入分散剂聚乙二醇(PEG-10000)对玻璃颗粒的分散性能、微观形貌和生物活性的影响。结果表明:没有加入PEG制得的纳米生物活性玻璃颗粒呈现不规则形态,粒径小于50nm。加有PEG的玻璃颗粒形状趋于规则的球形,分散性大大提高,颗粒粒径在40～100nm,而且加入PEG的浓度越高,制备的颗粒粒径越小。通过比较纳米级的生物活性玻璃与溶胶-凝胶生物活性玻璃在模拟人体体液(SBF)中的表面矿化研究,发现纳米生物活性玻璃比溶胶-凝胶生物活性玻璃有更高的生物活性。Nanoscale bioactive glass （NBG） powders were prepared using the sol-gel co-precipitation and freeze-drying methods. Effect of polyethylene glycol （PEG-10000） as a dispersing agent on their nanoscale morphology and bioactivity was investigated. The results showed that NBG particles prepared without addition of PEG were found with an irregular particle morphology and the particle size was less than 50 nm . With addition of PEG, the spherical bioactive glass particles formed and the particle size ranged in approximately 40-100 nm. With the increase of PEG concentration, the particle size decreased The in vitro bioactivity test in a simulated body fluid （SBF） demonstrated that NBG possessed a higher bioactivity than that of the sol-gel derived bioactive glass.

关 键 词：纳米粒子 生物活性玻璃 聚乙二醇 冷冻干燥 

分 类 号：TB321[一般工业技术—材料科学与工程]