葡聚糖修饰的纳米级超顺磁性氧化铁稳定性检测  

The stability study of superparamagnetic iron oxide nanoparticles modified by dextran

作　　者：李梦雅[1] 文明[1] 李少林[1] 

机构地区：[1]重庆医科大学附属第一医院放射科,重庆400016

出　　处：《重庆医科大学学报》2010年第3期396-399,共4页Journal of Chongqing Medical University

基　　金：国家自然科学基金(编号:30940021);重庆市自然科学基金(编号:2008BB5209);重庆市卫生局医学科研基金(编号:062025);重庆医科大学附属第一医院科研基金(编号:YXJJ2009-08)

摘　　要：目的:研究共沉淀法制备葡聚糖修饰的纳米级超顺磁性氧化铁的稳定性。方法:参照一般注射试剂的基本要求,对采用共沉淀法制备葡聚糖修饰的纳米级超顺磁性氧化铁液体,分别进行强化实验和长期实验,观察或测定样品的性状、pH值、铁浓度、粒径、饱和磁化强度及T2磁豫率等参数。结果:与实验前所检测的数据比较,实验后各项数据无统计学差异。结论:葡聚糖修饰的纳米级超顺磁性氧化铁稳定性好,为进一步将其作为磁共振成像对比剂及靶向基因载体研究奠定了基础。Objective：To study the stability of Superparamagnetic iron oxide（SPIO） nanoparticles modified by dextran prepared by coprecipitation.Methods：To evaluate its stability through compared the characteristic parameters which contained the character,pH,iron content,size,saturated magnetization and T2 relaxivity before and after the strengthen experimentation and the long-term experimentation.All that was carried according to the basic request of injection requirements.Results：The above characteristic parameters had no statistic differences between before experimentation and after experimentation.Conclusion：The research showed that SPIO made by coprecipitation had good stability,can be further used as the contrast media of magnetic resonance imaging and target gene carrier.

关 键 词：超顺磁性氧化铁 纳米粒子 稳定性 

分 类 号：R921.2[医药卫生—药学]