脂质体携载前列腺素E1对冠脉介入治疗后炎症因子的影响  

Liposomal prostaglandin E1 can reduce inflammatory factors and the incidence of adverse cardiac events for percutaneous coronary intervention

作　　者：梁文华[1] 丁继军 林飞[3] 唐亮[4] 李解贵[1] 彭寒林[1] 周炜[1] 

机构地区：[1]湖南省衡阳市解放军第169医院内三科,衡阳421002 [2]张家港奥洋医院心内科,张家港215600 [3]第二军医大学附属长海医院,上海200433 [4]中南大学湘雅二医院心内科,湖南410011

出　　处：《重庆医科大学学报》2010年第3期427-429,共3页Journal of Chongqing Medical University

摘　　要：目的:观察早期使用脂质载体前列腺素E1对经皮冠状动脉介入治疗(Percutaneous coronary intervention,PCI)患者血浆炎症因子的影响。方法:74例行PCI治疗的患者随机分成实验组和对照组。前者入选后给予PGE120μg+生理盐水40ml静脉注射,Bid×3d,对照组患者则不给。其余基础治疗措施相同。于PCI术前1d、术后2d、术后5d、术后4周查CRP、IL-6、TNF-α,并观察观察术后60d内早期心脏事件发生情况。结果:两组患者经PCI治疗后1d,CRP水平有所上升,与同组术前1d相比有显著差异(P<0.05),但与对照组相比均未见有差异(P>0.05)。术后5d～4周,实验组的水平已较术前有所下降(P<0.05),对照组较术前亦有下降(P<0.05),并且实验组CRP的水平较对照组下降更为明显(P>0.05)。炎症因子IL-6、TNF-α和CRP表现出一样的变化趋势。并且,用药期间2组未出现不良反应,安全性良好。结论:在PCI术后早期CRP、IL-6和TNF-α可有升高,但早期应用Lipo-PGE1后,可有效抑制炎症因子水平。Objective：To observe the inflammatory factors for early use of lipid carriers prostaglandin E1 on percutaneous coronary intervention（PCI）.Method：74 patients treated with PCI were randomly divided into experimental and control groups.PGE1 20μg ＋ 40 ml normal saline intravenously,Bid × 3 d,were used in experimental groups,but not to the patients in the control group.The basis treatment was the same.CRP,IL-6,TNF-α were checked in the pre-operative 1 d,after 2 d,after 5 d,after 4 w,and after 60 d,the early incidence of cardiac events were observed.Results：CRP levels in every patients for two groups increased at 1 d（P0.05）,CRP level in the experimental group compared with the control group were not different（P0.05）.After 5 d～4 w,CRP level in the experimental group were declined than 1 d（P 0.05）,also dropped than the control group（P 0.05）,and the level of CRP in the experimental group decreased more than the control group（P0.05）.Inflammatory factor IL-6,TNF-α and CRP showed the same trend.Conclusions：CRP,IL-6 and TNF-α may have increased in the early stage of post-PCI,and the use of Lipo-PGE1 may be effective in containing the level of inflammatory factors.

关 键 词：前列腺素E1 皮冠状动脉介入治疗 炎症因子 

分 类 号：R541.4[医药卫生—心血管疾病]