Polymorphisms of XPC Gene And Susceptibility of Esophageal Cancer  

作　　者：Xiang-xian Feng Pei-fen Duan Li-bing Wang Zu-xun Lu 

机构地区：[1]School of Public Health, Huazhong University of Science and Technology, Wuhan 430030, China [2]Department of Preventive medicine, Changzhi Medical College, Changzhi, Shanxi 046000, China

出　　处：《Chinese Journal of Cancer Research》2010年第1期49-54,共6页中国癌症研究（英文版）

基　　金：supported by a grant from Scholarship Council Fund of Shanxi Province (No.200565)

摘　　要：Objective： To explore the relationships of the polymorphisms of xeroderma pigmentosum C （XPC） and the susceptibility of esophageal cancer （EC） in Changzhi area, China. Methods： The study was conducted by a case-control study which included 196 cases of EC and 201 cases of controls. XPC PAT polymorphisms were determined with polymerase chain-restriction on fragment length polymorphism （PCR-RFLP）. Results： The frequencies of wild homozygote （PAT-/-）, mutation heterozygote （PAT-/＋） and mutation homozygote （PAT＋/＋） of XPC were 36.73%, 51.53% and 11.74% in case group, 37.81%, 52.24% and 9.95% in control group, respectively, and there was no significant difference between the two groups （X^2 =0.332, P=0.847）. There was no interaction between XPC PAT mutation genotype and xeroderma pigmentosum A （XPA） （S=0.85） and pickled food （S=0.81）. Conclusion： A genetic polymorphism in XPC may be not associated with esophageal cancer in Changzhi population.Objective： To explore the relationships of the polymorphisms of xeroderma pigmentosum C （XPC） and the susceptibility of esophageal cancer （EC） in Changzhi area, China. Methods： The study was conducted by a case-control study which included 196 cases of EC and 201 cases of controls. XPC PAT polymorphisms were determined with polymerase chain-restriction on fragment length polymorphism （PCR-RFLP）. Results： The frequencies of wild homozygote （PAT-/-）, mutation heterozygote （PAT-/＋） and mutation homozygote （PAT＋/＋） of XPC were 36.73%, 51.53% and 11.74% in case group, 37.81%, 52.24% and 9.95% in control group, respectively, and there was no significant difference between the two groups （X^2 =0.332, P=0.847）. There was no interaction between XPC PAT mutation genotype and xeroderma pigmentosum A （XPA） （S=0.85） and pickled food （S=0.81）. Conclusion： A genetic polymorphism in XPC may be not associated with esophageal cancer in Changzhi population.

关 键 词：Esophageal Cancer XPC PAT Genetic polymorphisms 

分 类 号：R735.1[医药卫生—肿瘤]