川崎病患儿血清白细胞介素-6、白细胞介素-8水平变化及其与冠状动脉损伤的关系  

Changes of Serum Interleukin-6,Interleukin-8 Levels and Their Associations with Coronary Artery Lesions in Children with Kawasaki Disease

作　　者：汪芸[1] 马官福[1] 伏瑾[1] 孙春荣[1] 马连华[1] 崔小岱[1] 李尔珍[1] 

机构地区：[1]首都儿科研究所附属儿童医院儿科,北京100020

出　　处：《实用儿科临床杂志》2010年第9期632-633,共2页Journal of Applied Clinical Pediatrics

基　　金：首都医学发展基金联合攻关项目(2002-1018)

摘　　要：目的观察川崎病(KD)患儿血清IL-6、IL-8水平变化,探讨其与冠状动脉损伤(CAL)的关系。方法采用前瞻性实验研究方法 ,研究对象为2003年10月-2005年12月本院住院的46例KD患儿(KD组),平均年龄2.21岁(5个月～8.75岁),根据超声结果将患儿分为CAL组(18例)和无CAL组(28例)。测定所有患儿血清IL-6、IL-8水平,16例健康体检儿童(健康对照组)也进行血清IL-6、IL-8检测。结果 1.KD组患儿治疗前血清IL-6、IL-8水平分别为52.39(24.39～134.46)ng.L-1和68.64(52.88～230.18)ng.L-1,均显著高于健康对照组[7.17(4.25～10.29)ng.L-1和10.34(9.60～11.57)ng.L-1],2组比较差异均有统计学意义(Pa<0.05),但二者无相关性(r=-0.166,P>0.1)。2.CAL组和无CAL组患儿IL-6水平分别为37.50(24.08～139.34)ng.L-1、31.21(19.67～87.90)ng.L-1,2组比较差异有统计学意义(P<0.05);CAL组和无CAL组患儿IL-8水平分别为47.18(16.98～109.72)ng.L-1和46.34(4.40～89.86)ng.L-1,2组比较差异无统计学意义(P>0.05);5例冠状动脉持续扩张患儿IL-6、IL-8水平在恢复期持续增高。结论 KD患儿血清IL-6、IL-8水平的增高与免疫性血管炎有关。IL-6对CAL的作用可能较IL-8更为重要,对高IL-6水平的患儿应注意有无CAL的存在。持续性IL-6、IL-8高水平表达,可能与临床部分KD患儿晚发性CAL有关。Objective To study the changes of serum IL -6, IL - 8 levels and to investigate their associations with coronary artery lesions （CAL） in children with Kawasaki disease （KD）. Methods From Oct. 2003 to Dec. 2005,46 children with KD （KD group） and 16 healthy children （ healthy control group） were recruited in this study. The age of KD group ranged from 5 months to 8.75 years. KD children were divided into CAL group （18 eases） and non- CAL group（28 eases）. Serum IL-6, IL-8 concentrations in KD group were compared to those of healthy control group. Results 1. The levels of serum IL - 6 and IL - 8 in KD group [ 52.39 （ 24.39 - 134.46） ng · L^- 1,68.64 （52.88-230.18） ng · L^-1 ]were significantly higher than those in healthy control group[7.17（4.25-10. 29） ng · L^-1,10. 34（9. 60-11.57） ng· L^-1] （ p, 〈 0.05 ）, and there was no correlation between them （ r = - 0. 166, P 〉 0.1 ）. 2. The level of serum IL - 6 in C AL group was significandy higher than that in non - CAL group[37.50（24.08 - 139.34） ng· L^-1 vs 31.21 （ 19.67 - 87.90） ng· L^-1 ,p 〈0.05]. The level of IL -8 was 47.18（ 16.98 - 109.72） ng· L^-1 in CAL group and 46.34（4.40 - 89.86） ng· L^-1 in non - CAL group, there was no significant difference between them（ P 〉 0.05 ）. The elevation of IL - 6, IL - 8 levels had continually existed in 5 convalescent children who were detec- ted coronary artery dilatation by ultrasound. Conclusions The levels of serum IL - 6, IL - g were markedly elevated in all children with KD, which can provide some evidences of the inflammation of coronary artery. IL -6 concentration were significantly elevated in CAL children, which might play a more important role in CAL than IL - 8. When high serum IL - 6 and IL - 8 concentrations were observed in children with KD, CAL might develop CAL in the subacute or convalescent phase.

关 键 词：皮肤黏膜淋巴结综合征 白细胞介素-6 白细胞介素-8 冠状动脉损伤 

分 类 号：R725.4[医药卫生—儿科]