蛞蝓胶囊对实验动物过敏性反应的影响  

Effect of Slug capsule on the anaphylaxis of experimental animals

作　　者：严鹏科[1] 李世煌 段才闻[3] 吴仲洪[1] 肖国宏[1] 谢金魁[3] 

机构地区：[1]广州医学院第三附属医院,广东广州510150 [2]郴州市第四人民医院心内科,湖南郴州423000 [3]南华大学药物药理研究所,湖南衡阳421001

出　　处：《中国医院药学杂志》2010年第9期746-748,共3页Chinese Journal of Hospital Pharmacy

基　　金：广州市科技攻关项目(编号:036J1001)

摘　　要：目的:观察蛞蝓胶囊对致豚鼠全身过敏反应的情况和大鼠被动皮肤过敏反应的影响。方法:用蛞蝓胶囊作为抗原,对豚鼠进行致敏和攻击。将SD大鼠随机分为蛞蝓胶囊高剂量和低剂量组、阳性对照组和生理盐水对照组,分别进行被动皮肤过敏反应实验,观察皮肤反应斑的光密度变化。结果:蛞蝓胶囊未引起豚鼠发生全身过敏反应。天花粉组的吸光度值与生理盐水组比较,差异有显著性。而蛞蝓胶囊组与生理盐水组比较,差异无显著性。提示蛞蝓胶囊不会引起大鼠同种被动皮肤过敏反应。结论:蛞蝓胶囊对实验动物无致敏性。OBJECTIVE To investigate the systemic anaphylaxis effect of Slug capsule injection on guinea pig and passive cutaneous anaphylaxis on rat. METHODS Using Slug capsule as antigen, carried on sensitizing and attacking of anaphylaxis on guinea pig. The rats were allocated to normal control group, positive drug group, Slug capsule high dosage group and Slug capsule low dosage group randomly. Optical density（OD） value of cutaneous reaction macula was detected after passive cutaneous anaphylaxis experiment. RESULTS Systemic anaphylaxis wasn＇t induced by Slug capsule on guinea pig. Compared with the normal control group, the OD value of trichosanthis group was elevated obviously. While there were no different between Slug capsule treated group and nomal control group. CONCLUSION Slug capsule causes no anaphylaxis on experimental animals.

关 键 词：蛞蝓胶囊 全身过敏性 被动皮肤过敏反应 

分 类 号：R285.6[医药卫生—中药学]