1186例次癫痫患者丙戊酸钠血药浓度监测分析  

Analysis of therapeutic drug monitoring data of valproic acid in 1186 cases of epileptics

作　　者：刘亦伟[1] 王长连[1] 黄品芳[1] 张陈枝[1] 

机构地区：[1]福建医科大学附属第一医院药学部,福建福州350005

出　　处：《中国医院药学杂志》2010年第9期775-777,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:通过丙戊酸钠(VPA)治疗癫痫病例的血药浓度监测及其疗效分析与评价,为临床合理用药提供参考。方法:回顾性分析癫痫患者VPA血药浓度监测数据,结合临床疗效及不良反应进行分组比较。统计学处理运用SPSS11.5软件。结果:在796例患者1186次VPA血药浓度监测中,治疗有效组88.4%(640/724),血药质量浓度落在50～100mg.L-1;无显效组78.9%(82/435),血药质量浓度<50mg.L-1;发生不良反应组77.8%(21/27),血药质量浓度>100mg.L-1。其他抗癫痫药可能降低VPA血药浓度而影响疗效。结论:VPA抗癫痫的疗效及不良反应与血药浓度密切相关。临床为实现个体化给药,应常规监测血药浓度。OBJECTIVE To guide rational use of anti epileptic drugs in clinical practice by analysis and evaluation of the therapeutic effect and the blood drug level of valproate serum concentration. METHODS The valproic acid concentration data were separated into some groups according to the therapeutic effect and adverse reaction, the data were retrospectively analyzed by SPSS 11.5 program. RESULTS By analyzing the TDM data of valproic acid in 1 186 cases （796 patients）, 88.4% （640/ 724） of the data which came from the effective team were between 50-100 mg.L^-1; 78. 9% （82/435） of the data which acquired from the non-significant effective group were less than 50 mg. L^-1; 77. 8% （21/27）of the serum concentration data were more than 100ug.mL^-1 in the group of which occurred adverse reactions. Other antiepileptic drugs may reduce the plasma concentration of valproic acid and interfere with the therapeutic effect. CONCLUSION The therapeutic effect and adverse reaction arose from valproic acid were closely related to plasma valproate concentration. For the realization of individual administration, the blood drug concentration should be monitored routinely.

关 键 词：丙戊酸钠 血药浓度 治疗药物监测 

分 类 号：R979.5[医药卫生—药品]