乳杆菌活菌胶囊辅助治疗妊娠期外阴阴道假丝酵母菌病的疗效观察  

Efficacy Observation of Accessory Lactobacillus Capsules Treatment for Vulvovaginal Candidiasis during Pregnancy

作　　者：王东红[1] 冉开琼[1] 叶春花[1] 谢和英[1] 杨高巧[1] 王明阳[1] 

机构地区：[1]遵义医学院附属医院妇产科,遵义市563003

出　　处：《中国药房》2010年第18期1689-1690,共2页China Pharmacy

摘　　要：目的:观察不同方法治疗妊娠期外阴阴道假丝酵母菌病(VVC)的疗效。方法:将320例妊娠期VVC患者随机分为2组,其中A组为制霉菌素组(153例),B组为乳杆菌活菌胶囊联合制霉菌素组(167例),比较2组有效率、复发率及妊娠结局。结果:A、B组有效率分别为64.71%、90.42%(P<0.05),复发率分别为15.69%、9.58%(P>0.05);B组早产及胎膜早破发生率分别为2.99%、4.48%,均低于A组的15.38%、19.23%(P<0.05)。结论:对妊娠期VVC,在应用抗真菌药物的前提下加用乳杆菌制剂,可提高疗效及改善妊娠结局。OBJECTIVE： To evaluate curative efficacy of different treatments for vulvovaginal candidiasis （VVC） during pregnancy. METHODS： 320 VVC patients during pregnancy were randomly divided into group A（treated with nystation,n=153） and group B（treated with nystatin and lactobacillus capsule,n=167）. Effective rate, recurrence rate and pregnancy outcome of two groups were compared. RESULTS： The effective rates were 64.71% for group A and 90.42% for group B（P0.05）. The recurrence rate of two groups were 15.69% and 9.58%（P0.05）. The incidence of premature birth and premature rupture of fetal membrane in B group were 2.99% and 4.48%, which was all lower than 15.38% and 19.23% of group A（P0.05）. CONCLUSION： Accessory lactobacillus capsule treatment can improve the curative efficacy of antibiotic in the treatment of VVC patients during pregnancy and pregnancy outcome.

关 键 词：外阴阴道假丝酵母菌病 妊娠期 乳杆菌活菌胶囊 制霉菌素 妊娠结局 

分 类 号：R969.4[医药卫生—药理学] R984[医药卫生—药学]