黄芪注射液治疗大鼠牙周炎作用研究  

Therapeutic Effects of Huangqi Injection in the Treatment of Periodontitis in Rats

作　　者：舒瑶[1] 王丽[2] 孟保华 

机构地区：[1]解放军军事医学科学院附属医院口腔科,北京市100071 [2]徐州医学院口腔系,徐州市221006 [3]成都康弘药业集团企业技术中心,成都市610036

出　　处：《中国药房》2010年第19期1736-1737,共2页China Pharmacy

基　　金：徐州医学院科研课题(09KJ22)

摘　　要：目的:研究黄芪注射液对大鼠牙周炎的治疗作用。方法:采用牙龈划割剥离加高糖饲料和高糖饮水喂养的方法复制大鼠牙周炎模型,以血液生化指标和临床观察指标考察黄芪注射液8.0g·kg-1剂量下连续给药10d的治疗作用。结果:黄芪注射液能显著降低牙周炎大鼠的血清白细胞、中性粒细胞等指标含量,对红细胞、血小板、血红蛋白无降低作用;同时能显著降低牙周炎大鼠的龈沟出血指数、菌斑指数、牙槽骨吸收值、牙齿松动度,而对探针深度、丧失值、牙周骨支持率等指标无明显改善。结论:黄芪注射液对大鼠牙周炎有一定的治疗作用。OBJECTIVE：To investigate the therapeutic effect of Huangqi injection in the treatment of periodontitis in rats.METHODS：Periodontitis model was induced by exposing and lacerating,supplying a high-glucose diet.They were given 8.0 g·kg^-1 Huangqi injection for 10 days.Therapeutic effect was evaluated with blood biochemical index and clinical index.RESULTS：Huangqi injection could decrease the level of leukocytes and neutrophils in periodontitis rats while had no effect on erythrocyte,platelet and hemoglobin.Huangqi injection could decrease the level of plaque index （PLI）,bleeding index （BI）,alveolar bone loss （ABL） and tooth mobility （TM） while had no significant effect on probing depth （PD）,periodontal bone support （PBS） and periodontal bone loss （PBL）.CONCLUSION：Huangqi injection has therapeutic effect on periodontitis in rats.

关 键 词：黄芪注射液 牙周炎 治疗作用 

分 类 号：R285[医药卫生—中药学] R97[医药卫生—中医学]