围绝经期妇女双能X线骨密度及其与体质指数、睾酮和雌二醇的相关性  

Analysis of bone mineral density tested by dual energy X-ray absorptiometry in 116 perimenopausal women and its correlation with body mass index, testosterone,and estradiol

作　　者：谢威[1] 张金山[1] 赵旦[2] 

机构地区：[1]广州医学院第三附属医院体检中心,510150 [2]广州医学院第三附属医院核医学科,510150

出　　处：《实用医学杂志》2010年第9期1557-1559,共3页The Journal of Practical Medicine

摘　　要：目的:分析围绝经期妇女低骨量及骨质疏松(osteoporosis,OP)发生情况,探讨骨密度(bone mineral density,BMD)与体质指数(body mass index,BMI)、血清雌二醇(estradiol,E2)和睾酮(testosterone,T)水平的相关性。方法:共116例在我院体检中心进行常规体检的围绝经期妇女,年龄42～56岁,平均47岁,根据BMI进行分组:低BMI组(BMI≤18)21人,正常BMI组(BMI为18～25)79人,超BMI组(BMI≥25)16人。采用双能X线骨密度吸收测定仪(dual energy X-ray absorptiometer,DEXA)检测腰椎(L2～4)、股骨颈、Ward′s三角区以及大转子的BMD,并检测血清E2和T水平。结果:围绝经期妇女低骨量检出率为19.0%(22/116),其中低BMI组(47.6%)显著高于正常BMI(13.9%)和超BMI组(6.25%),OP患者全部发生于低BMI组,检出率为28.6%。各部位的BMD与BMI成正相关(r=0.388～0.507,P=0.000)。此外,BMD与E2及T水平亦成正相关性(r=0.175～0.374,P<0.05)。结论:围绝经期妇女即有骨量减少情况,低BMI、低E2及低T水平可能是出现低骨量和发生OP的高危因素。Objective To analyze the events of bone mass loss and osteoporosis （OP） in perimenopausal women and to investigate correlation between bone mineral fensity （BMD） and body mass index （BMI）, testosterone, and estradiol. Methods One hundred and sixteen cases of perimenopausal women （42 - 56 years old with an average of 47） were separated into three groups according to BMI. There were 21 cases of low BMI （BMI ≤ 18）, 79 cases of normal BMI （BMI 18 - 25）, and 16 cases of supper BMI（BMI ≥ 25）. The BMD values of lumbar spine （L2-4）, femoral neck, Ward＇s triangle and great trochanter were examined by dual energy X-ray absorptiometer in all cases. Serum estradiol and testosterone were also measured. Results The incidence rate of bone mass loss was 19.0% （22/116） in all cases , and it was significantly higher in the group of low BMI group （47.6%） than that in the normal and supper BMI groups（13.9% and 6.25%, respectively） （P 〈 0.01）. OP were only found in the low BMI group with the incidence rate of 28.6%. The BMD values of all sites had positive correlation with the BMI（r =0.388 0.507, P = 0.000）. Estradiol and testosterone also had positive correlation with BMI（r = 0.175 - 0.374,P 〈 0.05）. Conclusions Bone mass loss could be found inperimenopausal women. Low BMI, estradiol, and testosterone would be the risk factors for bone mass loss and OP.

关 键 词：围绝经期 骨密度 体质指数 睾酮 雌二醇 

分 类 号：R580[医药卫生—内分泌]