慢性肾脏病患者进展为肾功能衰竭影响因素分析  

Analysis of progression risk factors of 112 cases of chronic kidney disease

作　　者：马立萍[1] 穆晓冬[1] 孙建洁[2] 陈宪英[3] 周景春[3] 李英[4] 

机构地区：[1]河北医科大学石油临床医学院血液净化科,河北廊坊065000 [2]河北医科大学石油临床医学院血液肾内科,河北廊坊065000 [3]河北医科大学石油临床医学院院内感染科,河北廊坊065000 [4]河北医科大学第三医院肾内科,石家庄050051

出　　处：《中国实用内科杂志》2010年第5期444-446,共3页Chinese Journal of Practical Internal Medicine

摘　　要：目的调查及分析慢性肾脏病(CKD)患者肾衰竭进展的相关危险因素。方法选择2007年5月至2009年5月在中国石油天然气集团公司中心医院、廊坊市第一人民医院、廊坊市第四人民医院和文安县医院因终末期肾病(ESRD)进行血液透析治疗的患者122例,用调查表登记患者一般资料、CKD进展情况、相关危险情况和进入透析治疗前的情况等资料,建立数据库进行统计学分析。结果 122例患者中,男76例,女46例,年龄(52.5±12.6)岁。各项因素中蛋白尿与CKD进展关系密切,有蛋白尿患者CKD的进展速度与无蛋白尿患者之间比较差异有统计学意义(P=0.044);年龄、性别、高血压和高血糖等因素也与CKD进展有关,但差异无统计学意义;本研究中未观察到高血脂和低蛋白饮食对CKD进展速度的影响。结论 CKD的进展受到多种因素影响,其中蛋白尿是重要的影响因素;此外,对CKD的早期诊断也亟待加强。Objective To survey and analyze the progressive risk factors of patients with chronic kidney disease（CKD）. Methods 122 cases of end-stage renal disease （ESRD） with hemodialysis from May 2007 to May 2009 were investigated in Langfang City. Their general information, progression of CKD, related risk factors and the state before dialysis were obtained and saved as a database,and then analyzed statistically. Results In 122 cases,the ratio of male to female was 1.65：1 and the average age was（52. 5±12. 6）years old. The risk factor that was most closely related to CKD was proteinuria,which might speed up the progression of CKD significantly（ P 〈 0. 05 ）,followed by age, sex, hypertension and hyperglycemia, which all seemed to speed up the progression of CKD, but without significant difference. In this study, the effects of hyperlipemia and low protein diet on progression of CKD were not observed. Conclusion The progression of CKD is affected by many factors and proteinuria is the most important risk factor. In addition, the publicity and education of CKD should also be strengthened.

关 键 词：慢性肾脏病 血液透析 蛋白尿 高血压 

分 类 号：R5[医药卫生—内科学]