配体靶向药物传递系统的研究进展  

Progress in ligand-drug delivery system

作　　者：吴镁春[1] 王驰[1] 

机构地区：[1]重庆医科大学药学院,重庆400016

出　　处：《中国新药杂志》2010年第7期569-572,共4页Chinese Journal of New Drugs

摘　　要：利用肿瘤细胞表面过度表达的某些生物大分子受体能够与其配体特异性结合的特点,用配体与药物结合,形成配体靶向药物递送系统。配体发挥导向物作用,将药物靶向递送到肿瘤细胞(或组织),实现主动靶向释药,提高药物的选择性,从而增加药效。文中介绍了以维生素(叶酸、维生素B12,维生素A)、蛋白质(转铁蛋白、低密度脂蛋白)、多糖(半乳糖、甘露糖、透明质酸)、整合素等生物大分子为配体的靶向药物递送系统研究进展。Biomacromolecular receptors over-expressed on the surface of tumor cells are able to connect with corresponding ligands specially.Ligand-drug delivery system is developed by linking drug with ligand.The drug can be delivered targeting to tumor cells or tissue with directing by ligand.Therefore,the drug is actively released to the target,and drug selectivity and action are increased.This paper summarized the ligand-drug delivery system which connect with ligands,such as vitamins （folic acid,vitamin B12,and vitamin A）,proteins （transferring and low density lipoprotein）,polysaccharides （galactose,mannose and hyaluronic acid）,and integrin.

关 键 词：受体 配体 靶向 配体靶向药物递送系统 

分 类 号：R979.1[医药卫生—药品]