氨酚伪麻美芬片Ⅱ/氨麻苯美片致重症多形性红斑型药疹  

Severe erythema multiforme-type drug eruption induced by paracetamol,pseudoephedrine hydrochloride and dextromethorphan hydrobromide tabletsⅡ/paracetamol,pseudoephedrine hydrochloride,diphenhydramine hydrochloride and dextromethorphan hydrobromide tablets

作　　者：张秀红[1] 陆一[1] 

机构地区：[1]无锡市人民医院药剂科,江苏无锡214023

出　　处：《药物不良反应杂志》2010年第2期113-113,116,共2页Adverse Drug Reactions Journal

摘　　要：1例55岁女性患者,因上呼吸道感染每天先后服用氨酚伪麻美芬片Ⅱ(日用片)1片及氨麻苯美片(夜用片)1片。2周后,患者面部出现红疹,且逐渐增多,延及躯干和四肢。并有口腔黏膜糜烂;结膜充血,睑缘处糜烂;脚趾处密集水疱;大阴唇可见红斑,T39.2℃。尿常规检查:WBC182.2个/μL,RBC89.6个/μL,酮体(+),白细胞酯酶(++),葡萄糖(++++),潜血(+++)。给予抗过敏、预防感染、对症及支持治疗。4d后病情好转,13d皮疹基本消退。A 55-year old woman received initially one tablet of paracetamol,pseudoephedrine hydrocholoride and dextromethorphan hydrobromide Tablets Ⅱ （day use tablets）,and subsequently one tablet of paracetamol,pseudoephedrine hydrochloride,diphenhydramine hydrochloride and dextromethorphan hydrobromide tablets （night use tablets）. Two weeks later,the patient developed facial erythema which gradually increased and progressed to involve her trunk and extremities. Meanwhile she experienced oral mucosa erosion,conjunctiva hyperemia,erosion in palpebral margin,numerous vesicles on toes,as well as erythema in labium majus. Her temperature was 39.2℃. Routine urine tests revealed the following values：WBC 182.2 cells/μL,RBC 89.6 cells/μL,ketone（＋）,leukocyte esterase（＋＋）,glucose（＋＋＋＋）,occult blood（＋＋＋）. She was given anti-allergic,preventing infective,symptomatic,and supportive treatments. Four days later,her condition improved and the erythema disappeared after 13 days.

关 键 词：氨酚伪麻美芬片Ⅱ/氨麻苯美片 不良反应 重症多形红斑型药疹 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]