那曲肝素钙致肝功能异常2例  

Abnormal liver function due to nadroparin calcium in two patients

作　　者：王玉柱[1] 常艳[1] 王庆[1] 路聪哲[1] 于晓红[1] 

机构地区：[1]解放军海军总医院干二科,北京100048

出　　处：《药物不良反应杂志》2010年第2期136-137,共2页Adverse Drug Reactions Journal

摘　　要：2例男性患者(年龄52、79岁),分别因脑梗死和不稳定型心绞痛给予那曲肝素钙6000IU,1次/12h皮下注射。例1于第6天检查肝功能示ALT169U/L;例2于第3天实验室检查示ALT246U/L,γ-GT521U/L,TBil28.5μmol/L,DBil8.9μmol/L。停用那曲肝素钙,静脉滴注多烯磷脂酰胆碱,随后肝功能逐渐好转。Two male patients,aged 52 and 79 years,received SC nadroparin calcium 6 000 IU every 12 hours for cerebral infarction and unstable angina pectoris,respectively. Liver function tests in patient 1 showed an ALT level of 169 U/L on day 6; and laboratory examinations in patient 2 revealed the following values on day 3：ALT 246 U/L,γ-GT 521 U/L,TBil 28.5 μmol/L,DBil 8.9 μmol/L. Nadroparin calcium was stopped and an IV infusion of polyene phosphatidylcholine was given. Subsequently,their liver function improved gradually.

关 键 词：那曲肝素钙 不良反应 肝功能异常 

分 类 号：R541.4[医药卫生—心血管疾病]