TGF-β/smads与腹膜纤维化及调节机制系列研究  

A Series Studies on Mechanism of TGF-β/Smads in Peritoneal Fibrosis and Regulating Pathway

作　　者：余学清[1] 

机构地区：[1]中山大学附属第一医院肾内科,广东广州510080

出　　处：《中山大学学报（医学科学版）》2010年第2期161-165,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：卫生部临床学科重点项目(卫规财函[2007]353);卫生部行业公益性项目(200802083);美国百特基金会Extramural Grant Program;广州市科技局重大专项(2004Z2-E0041)

摘　　要：腹膜纤维化是维持性腹膜透析(腹透)病人最重要的并发症,是导致腹膜结构和功能改变的主要原因,也是影响腹透病人长期存活和预后的重要因素。TGF-β是一种多功能的生长因子,也是多种器官和组织纤维化的关键因子。我们针对TGF-β及其信号蛋白Smads在腹膜纤维化中的作用机制及调控因素进行了下述几方面的研究:①TGF-β在腹膜纤维化中的作用及机制;②上调表达smad7在腹膜纤维化防治中的作用;③TGF-β/Smad在急性腹膜炎中的作用及机制;④调节TGF-β作用的信号通路及机制。我们系列研究的结果表明,TGF-β1/Smads信号通路在腹膜纤维化的过程中发挥了至关重要的作用,上调表达抑制性信号蛋白Samd7对于腹透相关腹膜纤维化的防治具有潜在临床应用价值。Peritoneal fibrosis is the most important complication in maintenance of peritoneal dialysis （PD）, also the main reason of the changes in peritoneal structure and function, the important factor affecting the long-term survival and prognosis in PD patients. TGF-β is a multifunctional growth factor and also a key factor in organ and tissue fibrosis. We had carried out the following series studies focused on the mechanism and regulatory factors of TGF-β and its signaling proteins- Smads, in peritoneal fibrosis： ①the role and mechanism of TGF-β in peritoneal fibrosis; ②Over-expressed Smad7 in prevention and treatment of peritoneal fibrosis; ③the role and mechanism of TGF-β/Smad in acute peritonitis; ④crosstalk between TGF-β and other signaling pathways. The Results showed that, TGF-β1/Smads signaling pathway played a crucial role in the process of peritoneal fibrosis, and over-expression of inhibitory signaling protein Samd7 had potential clinical value in prevention and treatment of PD-related peritoneal fibrosis.

关 键 词：转化生长因子Β 信号蛋白smads 腹膜纤维化 

分 类 号：R69[医药卫生—泌尿科学]