患者标本产超广谱β内酰胺酶细菌的分析  

Analysis on the extended sprectrum β lactamase producing bacteria in patients specimens

作　　者：沈定霞[1] 吴坚[1] 赵莉萍[1] 徐雅萍[1] 

机构地区：[1]解放军总医院微生物科

出　　处：《军医进修学院学报》1999年第1期26-28,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的：了解产超广谱β内酰胺酶细菌的种类及其对抗生素的敏感性。方法：用双纸片扩散试验从１９９７年我院患者标本中检测产超广谱β内酰胺酶的细菌，测定它们对抗生素的敏感性。结果：产超广谱β内酰胺酶细菌以大肠杆菌和肺炎克雷伯菌为主，从正常为无菌部位的标本中分离的菌株产酶者占４７％。体外药敏试验提示，产超广谱β内酰胺酶细菌对亚胺硫霉素全部敏感，对阿米卡星耐药率低，对氧哌嗪青霉素、三代头孢类抗生素及喹诺酮类耐药性高。结论：产超广谱β内酰胺酶细菌种类多。Objective:To observe the kinds and the sensitivity to antibiotics of extended spectrum β lactamase producing bacteria. Methods:Extended spectrum β lactamase producing bacteria were detected by double disk diffusion test in patients specimens, their susceptibility to antibiotics was also examined by routine test. Results:Extended sprectrum β lactamase producing bacteria in specimens of the sterile regions held the positive rate of 47%. Of which Escherichia coli and Klebsiella pneumonia account for the majority. All extended sprectrum β lactamase producing bacteria were sensitive to impenem. They and lower resistant rate to amikacin, higher resistant rate to piperocillin had third generation cephalosporins. Thery were also resistant to quinolone simultaneously. Conclusion:There are various kinds of extended sprectrum β lactamase producing bacteria with high resistance to many antibiotics in daily use.

关 键 词：细菌 超广谱 Β内酰胺酶 药敏性 头孢类抗生素 

分 类 号：R978.11[医药卫生—药品] R969.4[医药卫生—药学]