胃癌组织中微淋巴管密度与侵袭转移的关系  

Study of the relationship between the micro-lymphatic vessel density and invasion and metastasis in gastric carcinoma

作　　者：黄振步[1,2] 聂寒秋[3] 

机构地区：[1]温州医学院,浙江温州325000 [2]温州市中医院肿瘤科,浙江温州325000 [3]台州市立医院普外科,浙江台州318000

出　　处：《细胞与分子免疫学杂志》2010年第4期371-373,共3页Chinese Journal of Cellular and Molecular Immunology

摘　　要：目的:探讨胃癌微淋巴管密度(LMVD)与侵袭转移的相关性。方法:应用免疫组化SP法检测胃癌组织和正常胃组织淋巴管内皮细胞透明质酸受体-1(LYVE-1)的表达,并计数LMVD,分析LMVD与侵袭转移的关系。结果:胃癌组织癌周区处于开放状态的功能性微淋巴管明显增多。胃癌组织LMVD较正常胃组织LMVD增多,差异有统计学意义(P<0.05)。有淋巴结转移胃癌中LMVD明显多于无淋巴结转移者,直径≥5cm胃癌LMVD明显多于直径<5cm者,侵及浆膜胃癌组织LMVD明显多于未侵及浆膜者,差异均有统计学意义(P<0.05)。结论:胃癌组织LMVD与肿瘤大小、浸润深度和淋巴转移有密切关系,可以作为肿瘤诱导生成淋巴管研究的量化指标,有助于胃癌的预后判断及治疗方案的评价。AIM：To investigate the relationship between the micro-lymphatic vessel density（LMVD） and invasion and metastasis in gastric carcinoma. METHODS：The expression of LYVE-1 in 52 cases of gastric carcinoma was detected by immunohistochemical SP method,by which the LMVD was calculated. RESULTS：The lymphangiogenesis was shown in peritumoral tissue in gastric carcinoma.LMVD of gastric carcinoma was higher than that of normal gastric tissue（P〈0.05）. LMVD with lymphatic metastasis was higher than that without lymphatic metastasis（P〈0.05）; LMVD with big tumor（diameter〉5 cm）was higher than that with small tumor（diameter〈5 cm）（P〈0.05）; LMVD with serosal invasion was higher than that without serosal invasion（P〈0.05）. CONCLUSION：LMVD is closely related to lymph node metastasis,tumor size and invasive depth,which is helpful to determine the prognosis of gastric cancer and treatment program evaluation.

关 键 词：胃肿瘤 微淋巴管密度 淋巴管内皮细胞透明质酸受体-1 淋巴转移 

分 类 号：R392.11[医药卫生—免疫学]