尘螨变应原特异性免疫治疗慢性湿疹的疗效分析  

Effect Analysis of the Dust Mite Allergen-Specific Immunotherapy of Chronic Eczema

作　　者：石海云[1] 王学艳[1] 任华丽[1] 庄严[1] 

机构地区：[1]北京世纪坛医院(北京大学第九医院)变态反应科,北京100038

出　　处：《中国皮肤性病学杂志》2010年第5期424-426,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的探讨尘螨变应原特异性免疫治疗在慢性湿疹中的意义。方法选择尘螨变应原检测阳性的慢性湿疹患者46例,随机分为治疗组和对照组,两组均采用尘螨疫苗皮下注射,2次/周,治疗组采用1∶109(W/V)起始浓度,0.1mL剂量开始,快速递增注射,每次剂量递增1倍,对照组采用1∶1012(W/V)起始浓度,0.1mL开始,常规递增注射,每次剂量递增0.1mL,两组下一疗程均较上一疗程浓度增加10倍,疗程间不间断,至1∶102(W/V)的维持浓度后,剂量维持为0.5mL,2次/周,两组疗程最长均不超过1年,并分别在治疗后3,6,9,12月末对其EASI评分、瘙痒积分及用药变化情况进行比较,判定两组疗效。结果两组均有一定疗效,治疗组3,6,9,12月末有效率分别为17.39%,38.09%,64.70%,85.71%;对3年,照组则为0,5.26%,14.28%,63.63%。治疗组疗效明显优于对照组(P<0.05)。结论尘螨变应原特异性免疫治疗对慢性湿疹有一定疗效。Objective To study the value of allergen-specific immunotherapy with dust mite extract in chronic eczema. Methods Forth-six cases with chronic eczema who was tested positive for dust mites were selected and were randomly allocated to treatment group and control group. Hypodermic injection with dust mite extract was performed in both groups twice a week. Patients were treated with an initial concentration of 1： 10^9（W/V） in treatment group. The rapid dose escalation method was applied with an initial dose of 0. 1mL . Each dose doubled compared with the previous treatment. Patients were treated with an initial concentration of 1：10^12 （W/V）in control group. The regular dose escalation method was applied with an initial dose of 0. 1mL. Each dose increased 0. 1ml compared with the previous treatment. There is no interruption between the treatment course in two groups. The concentration increased 10 times every course until the maintenance concentration of 1 ： 10^2 （W/V） was achieved, and the dose was fixed at 0.5mL as a maintenance dose . The longest treatment course didn＇t exceed one year in both groups. EASI scores, pruritus scores and medication changes were assessed to evaluate the efficacy of two groups. Results Symptoms were improved in both groups. The total effective rate at the end of 3, 6,9,12 months in treatment group was 17.39%, 38.09%, 64.70%, 85.71% , respectively. In contrast, the control group was 0, 5.26% , 14.28% , 63.63% accordingly. Better efficiency were detected in the treatment group （ P 〈 0.05）. Conclusion Dust mite allergen-specific immunotherapy have a certain value in patients with chronic eczema.

关 键 词：尘螨 湿疹 免疫治疗 

分 类 号：R758.23[医药卫生—皮肤病学与性病学]