六味地黄控释片的处方优化及同步释放的研究  

Formulation Optimization of Liuwei Dihiang Osmotic Pump-Controlled Release Tablets and Synchronous Release

作　　者：胡容峰[1,2] 韩玲玲[1,3] 彭代银[1,2] 孙玉亮[1] 苏丹[1] 高宇[1] 

机构地区：[1]安徽中医学院药学院,合肥230031 [2]安徽省现代中药重点实验室,合肥230038 [3]安徽省食品药品检验所,合肥230051

出　　处：《世界科学技术-中医药现代化》2010年第2期217-221,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：安徽省教育厅安徽高校省级自然科学研究重点项目(KJ2009A112):粉末直接压片技术及应用研究;负责人:胡容峰

摘　　要：目的:探讨渗透泵技术实现中药复方多组分同步释放的可能性。方法:以六味地黄为模型药物,释放度测定采用高效液相色谱法,选择水溶性成分马钱苷和难溶性成分丹皮酚为指标成分,通过对控释片多种指标性成分释放度的测定,筛选最佳处方,并进行体外释药模型拟合。结果:渗透泵技术研制的六味地黄渗透泵控释片可以实现以水溶性成分马钱苷和难溶性成分丹皮酚为指标成分同步释放。结论:通过渗透泵处方与工艺的优化,有可能实现中药复方各指标性成分同步释放。This study aimed to investigate the possibility of using the osmotic pump technique to achieve the synchronous release of multi-component Chinese compounds. Liuwei Dihuang was used as a model drug. The release rate was determined by high performance liquid chromatography. Loganin and paeonol were selected respectively as a water-soluble component and an insoluble component, through the determination of release. The formulation was optimized, and the in vitro cumulative release data was collected for release model fitting. Synchronous release of loganin and paeonolas, the index components, was observed on Liuwei Dihuang Osmotic Pump-Controlled Release Tablets. The results showed that by optimizing the prescription and process via the osmotic pump preparation, it is possible to achieve the synchronous release of Chinese medicine compounds.

关 键 词：六味地黄 渗透泵 工艺 同步释放 

分 类 号：R943[医药卫生—药剂学]