虎金丸对CCl_4所致实验性肝损伤的保护作用  

Protective Effect of Hujin Pills on CCl 4 induced Experimental Liver Injury

作　　者：黄兆胜[1] 黎俏梅[1] 

机构地区：[1]广州中医药大学中药学院

出　　处：《中国实验方剂学杂志》1999年第2期21-23,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家中医药管理局资助

摘　　要：虎金丸ｉｇ小鼠，能显著降低ＣＣｌ４所致血中ＡＬＴ、ＡＳＴ、ＧＳＴ和肝中ＭＤＡ水平的升高；虎金丸ｉｇ大鼠制得药物血清后，以１０％浓度加入原代培养大鼠肝细胞培养液中，能显著降低１０ｍｍｏｌ／ＬＣＣｌ４所致培养液中ＡＬＴ和ＭＤＡ的升高，并使细胞存活率由５５．９０％提高至８２．４５％。After the mice were dosed with Hujin Pill for 6 days,the raised level of ALT,AST,GST in serum and MDA in liver caused by CCl 4 was ameliorated evidently.In addition,for primay cultured rat hepatocytes,rat serum containing Hujin Pills could remarkably decrease the raised level of ALT and MDA in the culture caused by 10 mmol/L CCl 4,and the cell viability was improved from 55 90% to 82 45%.

关 键 词：虎金丸 CCL4 肝损伤 保护作用 

分 类 号：R285.5[医药卫生—中药学] R259.75[医药卫生—中医学]