低钙透析对终末期肾病高血压患者的降压作用  

The antihypertensive effect of low calcium dialysis to the end-stage renal disease patients with hypertension

作　　者：曹义法 段建明[1] 刘俊华[1] 湛婉华 

机构地区：[1]广东省增城市新塘医院,广东增城511340

出　　处：《中国民族民间医药》2010年第9期62-63,共2页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：广州市县级市及乡镇医疗卫生单位新技术新项目推广应用项目项目编号:2009-XZL-23

摘　　要：目的:观察二种不同浓度钙离子透析液对终末期肾病(end-stage renal disease,ESRD)高血压患者的降压作用。方法:选取维持性血液透析的ESRD高血压患者18例,分二个阶段,先用含钙离子浓度1.5mmol/L(DCa1.5)透析液透析三个月,再用含钙离子浓度1.25mmol/L(DCa1.25)透析液透析三个月。观察透析开始(0h)、透析1小时(1h)、透析1个月及透析3个月结束时血压的变化;对比分析二种不同钙离子浓度透析各时段对血压的影响,同时观察对钙磷代谢的影响。结果:DCa1.5透析液透析收缩压(systolic bloodpressure,SBP)呈逐渐升高趋势,透析3个月SBP明显升高(P<0.05);而DCa1.25透析液透析SBP呈逐渐下降趋势,透析1个月时收缩压明显下降(P<0.05),3个月时SBP及舒张压(diastolic blood pressure,DBP)均明显下降,以SBP下降更为明显(P<0.01);而对血钙、血磷影响无统计学意义。结论:低钙(DCa1.25)透析可降低ESRD高血压患者的血压,对钙磷代谢无明显影响。Objective： To observe the two different concentrations of calcium dialysate on end - stage renal disease （ESRD） in patients with hypertension antihypertensive effect. Methods： Select the ESRD maintained hemodialysis patients with hypertension in 18 cases, sub -2 phases, first with the calcium ion concentration of 1. 5mmol / L （DCa1. 5） dialysate dialysis for three months, and then calcium ion concentration 1. 25mmol / L （DCal. 25） dialysate dialysis for three months. Observation of dialysis start （0h）, di- alysis 1 hour （lh）, dialysis 1 month and 3 months the end of dialysis blood pressure changes; comparative analysis of two different calcium concentrations dialysis on blood pressure effects of various periods, while observation of calcium and phosphorus metabolism. Results： DCal. 5 dialysate dialysis systolic blood pressure （systolic blood pressure, SBP） was gradually increased trend, dialysis 3 months SBP was significantly higher （P 〈 0. 05） ; while DCal. 25 dialysate dialysis SBP showed a gradual downward trend, dialysis 1 month when the systolic blood pressure decreased significantly （P 〈 0. 05 ）, 3 months, SBP and diastolic blood pressure （diastolic pressure, DBP） decreased significantly to SBP decline was more marked （P〈0. 01 ） ; while serum calcium, blood Phosphorus was no significant impact. Conclusion： The low calcium （DCa1. 25 ） dialysis ESRD patients with hypertension can reduce blood pressure, had no significant effect on calcium and phosphorus metabolism.

关 键 词：血液透析 钙离子 血压 

分 类 号：R692[医药卫生—泌尿科学]