乙型肝炎病毒E抗原抗体系统的变化与慢性肝病预后的关系  

Study of Relationship between HBe Antigen-Antibody System and Prognosis of Chronic Hepatopathy

作　　者：谢青山[1] 朱科伦[1] 杨华礼[1] 马佩球[1] 

机构地区：[1]广州医学院临床一系传染病学教研室,广州510182

出　　处：《现代临床医学生物工程学杂志》1999年第1期26-27,共2页Journal of Modern Clinical Medical Bioengineering

摘　　要：为了探索乙型肝炎病毒（HBV）E抗原抗体系统的变化与慢性肝病的肝损程度及肝癌发生是否有关系，本文采用Elisa法对243例不同慢性肝病患者进行乙型肝炎病毒E抗原抗体系统检测，同时采用PCR法进行HBVDNA的检测．其结果提示：180例抗-HBe阳性的血清检出101例HBVDNA阳性，其阳性率为56％（101／180）；同时发现抗-HBe的检出率在肝细胞癌（HCC）组、肝炎后肝硬化（LC）组、慢性肝炎（中、重度CH）组中分别为83％（57／69）、78％（54／69）、75％（54／72），明显高于慢性肝炎（轻度CH）组，其检出率为45％（15／33）．结果说明：HBeAg阴转和／或抗-HBe阳转并不意味着病毒复制水平明显降低，临床不具传染性；而且抗-HBe的出现与加重肝细胞损害程度或肝细胞癌变可能有一定的关系，不能忽视对病程的随访与监测。In order to probe the relationship between HBe antigen-antibody system and the damage ofliver cells or hepatocanceration, the authors detected HBeAg and HBeAb system by ELISA, andHBV-DNA by PCR in 243 patients. 101 out of 180 patients with positive HBeAb were HBV-DNApositive. The positive rate was 56%. At the same time, the positive rates of HBeAb in the groups ofhepatocarcinoma, liver cirrhosis, and chronic hepatitis (moderate and serious degree) were 83%, 78%,and 75% respectively. The rates were higher than that of mild Chronic hepatitis (45%). This resultssuggested that patients with negative conversion of HBeAg and positive conversion of HBeAb shouldnot mean the decrease of virus replication, and also should not mean clincal noninfection. The appear-ance of HBeAb was probably concerned with the damagc of liver cells or hepatocaneeration.

关 键 词：乙型肝炎病毒 抗-HBE 慢性 乙型肝炎 预后 

分 类 号：R512.620.7[医药卫生—内科学]