用强迫振荡技术评估中心及外周呼吸阻力  

ESTIMATING CENTRAL AND PERIPHERAL RESISTANCE BY USING FORCED OSCILLATION TECHNIQUE

作　　者：黄敏[1,2] 陈式苏[1,2] 李孟荣 曾碧新[1,2] 徐永安[1,2] 

机构地区：[1]温州医学院物理教研室 [2]温州医学院附属二院内科

出　　处：《中国医学物理学杂志》1999年第1期28-30,共3页Chinese Journal of Medical Physics

基　　金：浙江省自然科学基金

摘　　要：本文介绍一种用强迫振荡技术评估中心以及外周呼吸阻力的方法。通过测定大耳白兔的呼吸有效阻力，并进行中心阻力Ｒｃ和外周阻力Ｒｐ的分离。结果表明新斯的明注射组的外周阻力Ｒｐ比正常对照组有非常显著性增加（Ｐ＜０．００１），而中心阻力Ｒｃ无显著性差异（Ｐ＞０．０５）。中心气道狭窄组的中心阻力Ｒｃ比正常对照组有非常显著性增加（Ｐ＜０．００１），而外周阻力Ｒｐ无显著性差异（Ｐ＞０．０５），与理论预期一致。说明利用强迫振荡有效阻力的频率依赖性可以分离中心和外周呼吸阻力。This paper reports a theoretical method about estimating central and peripheral respiratory resistance by using forced oscillation technique.We fractionated total respiratory resistance into central and peripheral resistance by measuring the respiratory effective resistance of big ear white rabbits.The results of measurement showed that the peripheral resistance R p of the Neostigmine injection group was very much higher than that of the normal group ( P <0.001),but the difference of central resistance( R c ) didn′t reach a significant level( P >0.05).The central resistance( R c ) of the central airway structure group was very much highter than that of the normal group( P <0.001),but the difference of peripheral resistance( R p ) didn′t reach a significant level ( P >0.05).The above results were in agreement with the theoretical estimates.It is hence concluded that it may be possible to fractionate total respiratory resistance into central and peripheral components by using the frequency dependence of forced oscillatory effective resistance.

关 键 词：强迫振荡技术 呼吸阻力 诊断 阻塞性肺疾病 

分 类 号：R563.904[医药卫生—呼吸系统]