普鲁卡因胺对血小板及其开放管道系统形态结构改变的影响  

EFFECTS OF PROCAINAMIDE ON MORPHOLOGICAL,STRUCTURAL CHANGES OF BLOOD PLATELET AND ITS OPEN CANALICULAR SYSTEM

作　　者：单春文[1,2,3] 刘连璞[1,2,3] 林继红[1,2,3] 杨淑琴[1,2,3] 

机构地区：[1]第一军医大学药理教研室 [2]第一军医大学电镜室 [3]第一军医大学实验动物中心

出　　处：《中国医学物理学杂志》1999年第1期56-59,共4页Chinese Journal of Medical Physics

摘　　要：用比浊法、电镜观察法和体视学计量法研究普鲁卡因胺对血小板聚集、形态改变和开放管道系统改变的影响。结果：普鲁卡因胺明显地抑制血小板聚集反应，抑制率为７０．６％～９１．２％；抑制血小板形成伪足和粘附，抑制开放管道系统形态结构参数值的改变：体视计量学的各种形态学参数值随药物浓度增加而逐渐接近空白对照组的水平，但与生理盐水对照组比较有显著差异，说明ＰＡ显著地抑制血小板及其开放管道系统形态结构的改变。Tubidmetry,electron microscopy and stereology meassurement were used to study effects of procainamide (PA) on platelet aggregation,morphological,structural changes of blood platelet and its open canalicular system (OCS) .The results showed that PA inhibited significantly platelet aggregation (inhibition % was 70.6%～91.2%),producing pseudopod like process,adhesion and changes of parameter values of blood platelet,and also lowered the changes of morphology,structure and parameter values of OCS.The changing parameter values of stereology measurement with increasing drug concentration approached gradually the levels of blank group,but was significantly different to normal saline (NS).This showed that PA inhibited significanty morphological,structural changes of blood platelet and OCS.

关 键 词：普鲁卡因胺 血小板 电镜 开放管道系统 

分 类 号：R972.2[医药卫生—药品] R965[医药卫生—药学]