脑脉舒宁对大鼠主动脉条收缩的影响  

Effect of Naomaishuning on the contraction isolated rat aortic strips induced by calcium,norepinephrine and potassium

作　　者：王淑英[1] 王建刚[1] 李艳[1] 路西明[1] 吴银萍 

机构地区：[1]洛阳医学高等专科学校药理教研室

出　　处：《河南医学研究》1999年第1期11-12,共2页Henan Medical Research

基　　金：河南省科委资助

摘　　要：目的：探讨脑脉舒宁降压作用的机理。方法：采用大鼠胸主动脉条测定脑脉舒宁对去甲肾上腺素（ＮＥ）、ＣａＣｌ２的量效曲线以及对单剂量氯化钾所致收缩的影响。结果：脑脉舒宁能使ＮＥ、ＣａＣｌ２的量效曲线右移，最大反应压低，呈非竞争性拮抗；同时也可抑制高钾去极化引起的血管条收缩。结论：脑脉舒宁松弛血管平滑肌的作用与拮抗Ｃａ２＋有关。Objective: To explore the mechanism blood lowering effect of Naomaishuning.Methods: The effect of Naomaishuning on the contraction isolated rat aortic strips induced by calcium,norepinephrine and potassium.Results: The results showed that Naomaishuning shifted the cumulative concentration response curves for CaCl 2 and norepinephrine to right,and depressed their maximal responses.It appeared that the Naomaishuning was noncompetitive antagonist to CaCl 2 and norepinephrine,Naomaishuning also inhibited the contration of aortic strips evoked by single dose of KCl.Conclusion:The results suggested that Naomaishuning block calcium channels.

关 键 词：胸主动脉条 脑脉舒宁 降压 中药药理 

分 类 号：R285.5[医药卫生—中药学] R286.24[医药卫生—中医学]