妊高征患者外周血及脐静脉血一氧化氮及环磷酸鸟苷水平的测定及意义  

The change of maternal and umbilial venous blood nitric oxide and cyclic guansion monophosphate in patients with pregnancy induced hypertension

作　　者：杨建华[1] 杨平[1] 张曦 王兴玲 贾莉婷 

机构地区：[1]洛阳医学高等专科学校附属医院妇产科

出　　处：《河南医学研究》1999年第1期45-46,共2页Henan Medical Research

摘　　要：目的：探讨一氧化氮（ＮＯ）水平与妊高征的关系。方法：采用Ｇｒｅｉｓ法及放射免疫技术测定５０例妊高征患者（妊高征组），３０例正常晚期孕妇（晚孕组）外周血及脐静脉血ＮＯ及其第二信使环磷酸鸟苷（ｃＧＭＰ）水平，并以２５例健康未孕妇女（未孕组）作对照。结果：①妊高征组与晚孕组外周血ＮＯ及ｃＧＭＰ水平无显著差异（Ｐ＞００５），但均显著高于未孕组（Ｐ＜００５）；②妊高征组尤其中、重度妊高征脐静脉血ＮＯ及ｃＧＭＰ水平均显著高于晚孕组（Ｐ＜００５），且与收缩压及舒张压呈正相关关系（ｒ值分别为０４６，０５２；０４５，０５０，Ｐ＜００５）。结论：妊高征患者外周血ＮＯ及ｃＧＭＰ水平无明显变化，脐静脉血ＮＯ及ｃＧＭＰ水平升高，提示ＮＯ并非是妊高征发生、发展的根本原因，可能是脐－胎盘循环对血压升高、胎盘缺氧的代偿性反应。Objective: To determine the relationship between nitric oxide (NO) and pregnancy induced hypertension (PIH).Methods: 50 women with PIH,30 normal late trimester pregnant women (NLP) and 25 nonpregnant women (NPW) were studied.The concentrations of NO and the second messeger-cyclic guanosine monophosphate (cGMP) were measured by Greiss reaction and radioimmunoassay,respectively.Results: ①In materal circulation,concentrations of NO and cGMP in PIH and NLP group were significantly higher than those of the NPW group ( P <0.05),but there was no significant difference in the PIH and the NLP group ( P >0.05);②Concentrations of NO and cGMP were found significantly greater in umbilious venous blood of the PIH group than those in the NLP group ( P <0.05) Conclusion: NO is not an important reason resulting in PIH,level of NO increasing in the fetoplacental circulation may be a compensatory response to the high level of blood pression and ischemia of placenta.

关 键 词：一氧化氮 环磷酸鸟苷 妊娠高血压 外周血脐血 

分 类 号：R714.246[医药卫生—妇产科学]