组织工程技术及其材料在防治运动损伤导致肌腱粘连中的应用  

Application of tissue engineering techniques and materials in prevention and treatment of tendon adhesion induced by movement injury

作　　者：王向东[1] 马会清[2] 赵芸娜[2] 马宝娟[3] 刘荣华[4] 

机构地区：[1]河北科技师范学院体育系,河北省秦皇岛市066004 [2]河北建材职业技术学院体育教学部,河北省秦皇岛市066000 [3]石家庄信息工程职业学院,河北省石家庄市050035 [4]河北科技师范学院欧美学院体育教学部,河北省秦皇岛市066004

出　　处：《中国组织工程研究与临床康复》2009年第51期10157-10160,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:研究证实活体肌腱的愈合是内源性愈合和外源性愈合共同作用的结果,而外源性愈合又是肌腱发生粘连的主要原因,影响肌腱功能恢复。目的:探讨组织工程技术及其材料在防治运动损伤导致肌腱粘连中的应用。方法:以"运动损伤、生物材料、组织工程、肌腱粘连"为检索词,在中国期刊全文数据库(1990-01/2000-12)查阅发表的关于肌腱生物力学性能、可吸收生物材料聚羟基乙酸、肌腱细胞在体外构建组织工程化肌腱、生物膜、几丁糖、可吸收性防粘连膜、透明质酸钠、生物蛋白胶等生物材料预防肌腱粘连的随机动物对照实验和临床应用的文献,通过对文献资料的综合分析以及随访和功能评价,对组织工程预防肌腱粘连的临床应用进行全面总结。结果与结论:初检得到61篇文献,阅读标题和摘要进行初筛,排除因研究目的与此文无关的31篇,内容重复性的研究9篇,共保留21篇文献进行分析。肌腱粘连是指肌腱损伤修复过程中周围组织的增生和侵入,随着人们对肌腱修复愈合理论认识的深入,防止肌腱粘连的组织工程应用越来越多。肌腱愈合由内、外源愈合共同作用,以内源性愈合方式为主,同时又与腱鞘、腱纽及滑液等条件有密切联系;肌腱粘连多是由于外源性愈合参与过多及腱周损坏所致。组织工程是一种新技术,在其实施过程中广泛应用其新的生物材料,解决肌腱损伤和软骨坏死等问题,目的在于使组织重建,能够达到防粘连的临床效果。BACKGROUND：Previous studies have confirmed that healing of in vivo tendon is the outcome of interaction between endogenous healing and exogenous healing.Exogenous healing is a main reason for tendon adhesion,and affects the recovery of tendon function.OBJECTIVE：To explore application of tissue engineering technique and its materials in prevention and treatment of tendon adhesion induced by movement injury.METHODS：Using the of ＂movement injury,biomaterial,tissue engineering,tendon adhesion＂,we retrieved randomized animal controlled studies and clinical application literatures addressing tendon biomechanics function,adsorbable biomaterial polyglycolic acid,tendon cells-constructed tissue engineered tendon in vitro,biomembrane,chitosan,adsorbable antistick membrane,sodium hyaluronate,bioprotein gel and so on in prevention of tendon adhesion in Chinese Journal Full-text Database published from January 1990 to December 2000.By aggregate analysis of literature data,follow-up and function evaluation,this article summarized clinical application of tissue engineered techniques and materials in prevention of tendon adhesion.RESULTS AND CONCLUSION：A total of 61 literatures were primarily obtained.Following reading titles and abstracts,31 literatures of irrelevant objectives and contents,and 9 literatures of repetitive contents were excluded.Totally 21 literatures were included for analysis.Tendon adhesion refers to hyperplasia and invasion of surrounding tissues during repair of tendon damage.With the deep understanding of tendon repair healing,application of tissue engineering to preventing tendon adhesion became more and more.Tendon healing is an interaction between endogenous healing and exogenous healing,and mainly endogenous healing,which was simultaneously associated with tendon sheath,vincula tendinum and synovial fluid.Tendon adhesion is mainly induced by excessive action of exogenous healing and damage to surrounding tissues.Tissue engineering is a novel technique.Novel biomaterials are widely used in t

关 键 词：组织工程 运动损伤 肌腱 粘连 生物材料 

分 类 号：R318[医药卫生—生物医学工程]