同种异体神经移植去抗原性的预处理:应用与前景  

Advancement of pretreatment to decrease antigenicity in homologous nerve transplantation

作　　者：刘新胜[1] 王伟[1] 

机构地区：[1]锦州市中心医院骨科,辽宁省锦州市121001

出　　处：《中国组织工程研究与临床康复》2009年第53期10525-10528,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：对于周围神经损伤,自体神经移植是最佳的治疗方法。但自体神经移植会带来供区功能缺失,目前多趋向于异体神经移植。异体神经移植成功的关键是降低神经移植体的抗原性。降低抗原性的方法现在多重于物理和化学法,相对于物理法,经过化学脱细胞方法处理后的异体神经移植效果良好。文章介绍了异体神经的免疫反应和神经移植体的特征,探讨了同种异体神经降低免疫抗原性的预处理方法,经过分析得出:一种或多种方法联合降低异体神经抗原性将是未来的研究课题。Autogenous nerve transplantation is the best means for treating peripheral nerve injury.However,it would detriments function of donor area.Therefore,homologous nerve transplantation is adopted in clinic.The key of successful nerve allograft transplantation is to reduce nerve allograft antigenicity.Compared to physics method,chemistry method achieved a better result in reducing antigenicity of allograft nerve.Here,we introduce immune response and characteristics of grafts following homologous nerve transplantation,discuss the pretreatment method which can reduce the antigenicity.And propose that the combination of one or many kinds of methods would decrease the antigenicity of homogenous nerve in future.

关 键 词：周围神经 异体神经移植 预处理 

分 类 号：R318[医药卫生—生物医学工程]