免疫耐受性树突状细胞在移植免疫中的作用及其分子机制  

Roles and mechanism of tolerogenic dendritic cells in transplantation immunity

作　　者：付必莽[1,2] 胡安斌[1] 何晓顺[1] 张捷[2] 黄洁夫[1] 

机构地区：[1]中山大学附属第一医院器官移植中心,广东省广州市510080 [2]昆明医学院第二附属医院肝胆外科,云南省肝胆外科研究所,云南省昆明市650101

出　　处：《中国组织工程研究与临床康复》2009年第53期10529-10532,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：广东省自然科学基金(06104600);美国中华医学基金会(06-837)~~

摘　　要：新的研究发现一种半成熟树突状细胞亚群,其高表达主要组织相容性复合体II、中等表达CD40、CD80和CD86等分子,在自身免疫性疾病中表现出诱导免疫耐受的潜能,其与未成熟树突状细胞一道被认为是致耐受细胞。这使过去将树突状细胞分为未成熟和成熟两种类型的概念受到挑战。但是,它们在移植免疫中的具体作用和机制仍未完全明了。文章对致耐受树突状细胞的体内迁移过程、在移植免疫中分子机制和体外获得等方面的最新进展进行综合分析和热点追踪,为进一步理解和研究致耐受树突状细胞在移植免疫反应中的作用拓宽视野。It has been shown,however,that in terms of immune function,a transitional stage of dendritic cell maturation exists between immature myeloid dendritic cells （imDCs） and mature dendritic cells （DCs）,which were named semimature dendritic cells （smDCs）.Therefore,the theory that DCs can be classified as imDCs and mDCs has been challenged because of finding smDCs.SmDCs and imDCs are regarded as tolerogenic dendritc cells while what concrete mechanism taken by smDCs and imDCs in transplantation immunity has yet to know.The authors analyzed the important roles and the advanced molecular mechanism of smDCs and imDCs in transplantation immunity in order to update and widen understand underlying tolerogenic dendritic cells.

关 键 词：免疫耐受 树突状细胞 移植免疫 

分 类 号：R318[医药卫生—生物医学工程]