胆酸负荷对绵羊和大鼠血浆(血清)甘胆酸浓度的影响  

Effects of Exogenous Cholic Acid on the Concentration of Cholaneglycinate in Sheep Plasma and Rat Serum

作　　者：时浩[1,2] 朱祖康[1,2] 卢青 孙敬方[1,2] 毛鑫智[1,2] 

机构地区：[1]南京农业大学动物生理生化实验室 [2]南京军区总医院动物实验科

出　　处：《畜牧与兽医》1999年第1期14-16,共3页Animal Husbandry & Veterinary Medicine

摘　　要：湖羊通过颈静脉插管灌注较高剂量的胆酸和大鼠通过尾静脉给予不同剂量的胆酸造成胆酸负荷，研究其对血浆（血清）甘胆酸（ＣＧ）浓度的影响，结果表明：湖羊血浆ＣＧ浓度在灌注胆酸后呈波动性变化，在１８ｈ和１３８ｈ显著高于灌注前。大鼠以中胆酸组血清ＣＧ变动最为显著，灌注４ｈ后开始升高，１８ｈ后达到显著水平，一直持续至１３８ｈ，并在１８，９０，１１４和１３８ｈ显著高于对照组；低胆酸组仅在灌注后１８ｈ血清ＣＧ显著高于对照组，其他时间变化不显著；而高胆酸组在灌注后４２，６６，９０和１１４ｈ显著高于灌注前。Hu sheep and SD rats were given exogenous cholic acid to observe the variation of Cholaneglycinate(CG)concentrations in the plasma(or serum). The results were as follows:CG concentration in sheep plasma varied fluctuantly, increasing to a significant level at 42 and 138 h after injection. When three groups of SD rats were treated with different dose of cholic acid,CG concentrations in the serum appear to rise with significantly high concentrations at hour 18,90,114 and 138 in medium dose group compared with the control group. In low and high dose groups,CG concentrations were not changed with an exception at hour 18 in the low dose gruop.

关 键 词：湖羊 大鼠 甘胆酸 胆酸负荷 

分 类 号：S852.2[农业科学—基础兽医学]