榼藤子含硫酰胺类化学成分的研究(英文)  

Sulfur-containing amides from Entada phaseoloides

作　　者：熊慧[1] 肖二[1] 赵应红[2] 杨光忠[1] 梅之南[1] 

机构地区：[1]中南民族大学药学院,湖北武汉430074 [2]西双版纳州民族医药研究所,云南西双版纳666100

出　　处：《药学学报》2010年第5期624-626,共3页Acta Pharmaceutica Sinica

基　　金：Project supported by the 11th Five-year Plan of Ministry of Science and Technology of the People's Republic of China (No.2007BAI48B08)

摘　　要：为研究榼藤子[Entada phaseoloides(L.)Merr.]种仁的化学成分,利用正反相硅胶柱色谱、制备HPLC分离纯化,通过现代波谱学技术鉴定结构。从70%乙醇提取物的正丁醇萃取部位分离得到4个含硫酰胺类化合物,分别为entadamideA-β-D-glucopyranosyl-(1→3)-β-D-glucopyranoside(1)、entadamideA(2)、entadamideA-β-D-glucopyranoside(3)和clinacosideC(4)。化合物1为新化合物,化合物4为首次从该属中分离得到。To study the chemical constituents of the Entada phaseoloides （L.） Merr.,seeds of Entada phaseoloides were extracted with 70% ethanol at room temperature.Isolation and purification were performed by silica gel,reversed-phase silica gel column chromatography and semi-preparative HPLC.Structures of the pure compounds were established on the basis of spectral analysis.Four sulfur-containing amide compounds were isolated from the n-BuOH-soluble fraction and identified as entadamide A-β-D-glucopyranosyl-（1→3）-β-D-glucopyranoside （1）,entadamide A （2）,entadamide A-β-D-glucopyranoside （3） and clinacoside C （4）.Compound 1 is a new compound.Compound 4 is isolated from the genus Entada for the first time.

关 键 词：榼藤子 化学成分 含硫酰胺 

分 类 号：R284.1[医药卫生—中药学]