磷酸钙骨水泥/氨磷汀/顺铂复合体体外药物缓释及体内修复骨缺损和抑瘤实验  

Drug Delivery of CPC/Amifostine/Cisplatin Complex in vitro and Its Ability in Repairing Bone Defect and Eliminating Tumor in vivo

作　　者：刘彦宁[1] 刘淼[1] 任鹏宇[2] 

机构地区：[1]西安交通大学医学院第一附属医院骨科,西安710061 [2]陕西省人民医院骨科,西安710061

出　　处：《四川大学学报（医学版）》2010年第3期471-475,共5页Journal of Sichuan University(Medical Sciences)

基　　金：陕西省科学技术研究发展计划项目(2007K09-09)资助

摘　　要：目的探讨磷酸钙骨水泥/氨磷汀/顺铂(CPC/amifostine/cisplatin)复合体在填充和重建肿瘤性骨缺损中的可行性。方法在体外测定CPC/amifostine/cisplatin复合体缓释药物的情况,建立兔股骨骨缺损和裸鼠骨肉瘤模型,植入CPC/amifostine/cisplatin复合体后测定缺损修复情况和对肿瘤的抑制能力。结果 CPC/amifostine/cisplatin复合体和CPC具有相似的骨修复情况,同时具有CPC所没有的持续缓释药物的能力和抑制骨肉瘤生长的能力。结论 CPC/amifostine/cisplatin复合体用作肿瘤性骨缺损的填充材料是可行的。Objective To investigate the feasibility of using calcium phosphate cement/amifostine/cisplatin complex to fill and repair bone defect caused by tumor resection.Methods Drug concentration in the CPC/amifostine/cisplatin complex was determined.Rabbits with bone defect and rats with osteosarcoma were implanted with CPC and CPC/amifostine/cisplatin complex.Results Similar bone growth was observed in the femurs of rabbits implanted with CPC/amifostine/cisplatin complex and those implanted with CPC.CPC/amifostine/cisplatin complex delivered amifostine and cisplatin consistently and eliminated osteosarcoma cells implanted in the rats.Conclusion CPC/amifostine/cisplatin complex repairs bone defect caused by tumors as a filling material.

关 键 词：磷酸钙骨水泥 氨磷汀 顺铂 骨肉瘤 骨缺损 药物缓释 

分 类 号：R687[医药卫生—骨科学]