肝豆灵及谷胱甘肽口服治疗肝豆状核变性临床研究  

Study of Gandouling Tablet and Glutathione on Hepatolenticular Degeneration

作　　者：张波[1] 江婷战[1] 王晓旸[1] 黄为[1] 童建兵[1] 陈永华[1] 刘妮[1] 曹仕健[1] 方媛媛[1] 杨雄杰[1] 

机构地区：[1]安徽省中医学院第一附属医院,合肥230031

出　　处：《中国中医急症》2010年第5期760-761,763,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家中医药管理局"十一五"重点专科专病项目建设基金项目(No12J1X1L102B101)

摘　　要：目的观察肝豆灵及谷胱甘肽口服治疗肝豆状核变性的疗效及不良反应,并与二巯基丁二酸胶囊及青霉胺相比较。方法将患者167例随机分为四组,A组接受谷胱甘肽口服及常规药物(肝豆灵片及葡萄糖酸锌片)治疗,B组接受二巯基丁二酸胶囊口服及常规药物治疗,C组接受青霉胺片口服及常规药物治疗,D组接受常规药物治疗;治疗12周。结果A、B、C组疗效相近,均优于D组。结论谷胱甘肽合肝豆灵口服治疗肝豆状核变性与二巯基丁二酸胶囊、青霉胺同样具有确切疗效,其安全性更优。Objective：To observe the efficacy and the side-reactions of the oral Gandouling Tablet and glutathione in hepatolentcular degeneration and to compare these aspects with the dimercaptosuccinic acid capsules and penicillamine.Methods： 167 confirmed cases were randomly divided into 4 groups.Group A was received glutathione and conventional drugs （zinc gluconate tablet and Gandouling Tablet）.Group B was used dimercaptosuccinic acid capsules and conventional drugs.Group C was accepted penicillamine tablets and conventional drugs.Group D was received conventional drugs only.These treatments were lasted for 12 weeks.Results：The efficacy of the group D was worse than those of the other 3 groups.The side-reaction rate of the C group was higher that those of the other 3 groups.Conclusion：There are exact curative in Glutathione adding Gandouling Tablet and dimercaptosuccinic acid capsules and penicillamine in hepatolentcular degeneration. The safety of the Glutathione adding Gandouling Tablet is superior to that of the dimercaptosuccinic acid capsules and penicillamine.

关 键 词：肝豆状核变性 谷胱甘肽 青霉胺 二巯基丁二酸胶囊 肝豆灵 

分 类 号：R589[医药卫生—内分泌]