服用小剂量氢氯噻嗪后肾素-血管紧张素-醛固酮系统与血糖变化的关系  

Association between the activity of renin angiotensin aldostetone system and variety of glucose after small dose hydrochlorothiazide therapy

作　　者：李云[1] 杨鹏[2] 王丽晔[3] 刘秀荣[3] 于青[3] 侯国盛[3] 李东贤[3] 吴寿岭[3] 

机构地区：[1]华北煤炭医学院预防医学教研室,唐山063000 [2]华北煤炭医学院附属医院神经外科,唐山063000 [3]华北煤炭医学院附属开滦医院心内科,唐山063000

出　　处：《中国糖尿病杂志》2010年第5期364-366,共3页Chinese Journal of Diabetes

摘　　要：目的探讨服用氢氯噻嗪后的肾素-血管紧张素-醛固酮系统(R AAS)激活对血糖水平变化是否有预测作用。方法选择了119例原发性高血压患者,给予氢氯噻嗪,分析服药6周时RAAS活性变化与服药1年后血糖水平之间的关系。结果校正其他可能影响血糖水平变化的因素后,没有观察到服药6周时RAAS变化与1年后血糖水平变化之间存在相关性。结论原发性高血压患者服用氢氯噻嗪(12.5mg,1/d)6周后RAAS活性激活,1年后的血糖水平并未升高,二者之间的变化不存在相关性。尚不能根据服用氢氯噻嗪6周时的RAAS活性变化预测1年后的血糖水平,小剂量氢氯噻嗪对血糖未发生影响。Objective To investigate whether activity of RAAS could predict the glucose variation after hydrochlorothiazide therapy. Methods A total of 119 hypertensive patients were recruited. The activity of RAAS was measured after six weeks of hydrochlorothiazide treatment and the glucose level was measured after one year. Analysis of mutal changes of RAAS and glucose was performed. Results As compared with patients with normal RAAS level, the glucose level （retool/L） in patients with RAAS overactivity was not significantly higher （5. 65 vs 5. 20 for PRA, 5.16 vs 5.42 for ACE, 5.25 vs 5.34 for ATII, 5.29 vs 5. 07 for ALD, all P〈 0. 05）. After adjusting for covariates, there was no association between the overactivity of RAAS and variety of glucose after treatment with hydrochlorothiazide for one year. Conclusions There is no association between the overactivity of RAAS and variety of glucose after treatment with small dose of hydrochlorothiazide for one year in hypertensive patients.

关 键 词：肾素 血管紧张素 血糖 

分 类 号：R544.1[医药卫生—心血管疾病]