左卡尼汀联合曲美他嗪治疗老年缺血性心肌病心力衰竭的疗效观察  

Clinical Efficacy of Levoearnitine Combined with Trimetazidine in the Treatment of Ischemic Cardiomyopathy Heart Failure in Elderly

作　　者：钟淼[1] 李婷婷[1] 史若飞[1] 

机构地区：[1]重庆市急救医疗中心老年科,重庆市400014

出　　处：《中国药房》2010年第20期1872-1874,共3页China Pharmacy

摘　　要：目的:观察左卡尼汀联合曲美他嗪治疗老年缺血性心肌病(ICM)心力衰竭的短期疗效。方法:选择老年ICM心力衰竭患者64例,随机分为对照组和观察组,各32例。2组患者均接受调脂、抗血小板和抗心肌缺血的基础治疗以及常规抗心衰治疗,观察组在此基础上静脉滴注左卡尼汀并口服曲美他嗪。疗程均为2周。观察2组患者治疗前后心功能分级、实验室检查各指标以及采用彩色多普勒超声测量左室舒张末内径(LVEDD)、左室收缩末内径(LVESD)及左室射血分数(LVEF)。结果:观察组的心功能、LVEDD、LVESD、LVEF明显优于对照组,差异有统计学意义(P<0.05),且无肝肾功能异常。结论:左卡尼汀联合曲美他嗪治疗老年ICM心力衰竭短期疗效显著,且无明显不良反应。OBJECTIVE：To explore clinical efficacy of levoearnitine combined with trimetazidine in the treatment of ischemic cardiomyopathy（ICM） heart failure in elderly patients.METHODS：64 ICM elderly patients with heart failure were randomly divided into control group and observation group（n=32）.Both group were given therapy of regulating blood lipid,antiplatelet,anti ischemia and conventional anti-heart failure therapy.Observation group were additionally intravenously injected with levoearnitine and given oral dose of trimetazidine for 2 weeks.Cardiac function classification,left ventricular end-diastolic diameter（LVEDD）,left ventricular end systolic diameter（LVESD） and left ventricular ejection fraction（LVEF） of patients were determined before and after treatment.RESULTS：The cardiac function and the level of LVEDD,LVESD and LVEF in observation group were all significantly better than in control group.There were statistical significance in difference between two groups（P0.05） without disorder of liver and kidney function.CONCLUSION：Levoearnitine combined with trimetazidine have sound short effect on heart failure in ICM elderly patients without obvious adverse reaction.

关 键 词：左卡尼汀 曲美他嗪 缺血性心肌病 心力衰竭 疗效观察 

分 类 号：R541.6[医药卫生—心血管疾病]