静脉推注胺碘酮与西地兰转复阵发性心房颤动的疗效比较  

Comparison of Clinical Efficacy of Amiodarone and Cedilanid in the Treatment of Paroxysmal Atrial Fibrillation with Intravenous Administration

作　　者：熊刚 张后民 

机构地区：[1]重庆市三峡医药高等专科学校第二附属医院内科,重庆市404000

出　　处：《中国药房》2010年第20期1874-1875,共2页China Pharmacy

摘　　要：目的:比较静脉应用胺碘酮与西地兰对阵发性心房颤动(AF)的转复及心室率控制情况。方法:47例阵发性AF患者随机分成胺碘酮组24例、西地兰组23例,分别静脉推注胺碘酮150～600mg、西地兰0.2～0.6mg,观察各组AF的转复、心室率变化情况及不良反应。结果:胺碘酮组转复有效率显著高于西地兰组(P<0.01);2组治疗前、后的平均心室率差异均有统计学意义(P<0.01),但胺碘酮组疗效更佳,且2组比较有显著性差异(P<0.01)。结论:胺碘酮转复心律有效率及心室率降低作用均优于西地兰,且副作用较少。OBJECTIVE：To compare amiodarone and cedilanid in the treatment of paroxysmal atrial fibrillation（AF） with intravenous administration and control of heart rate.METHODS：47 AF patients were randomly given 150～600 mg amiodarone（amiodarone group,n=24） and 0.2～0.6 mg cedilanid（cedilanid group,n=23） intravenously.The outcome,change of heart rate and adverse drug reaction of 2 groups were observed.RESULTS：Effective rate of amiodarone group was significantly higher than that of cedilanid groups（P0.01）.There were statistical significance in difference of heart rate before and after treatment（P0.01）.Clinical efficacy of amiodarone group was superior to cedilanid groups.There were signigicant difference between 2 groups（P0.01）.CONCLUSION：Amiodarone is more effective than cedilanid in decreasing heart rate with less ADR.Amiodarone is safe and effective in the treatment of PAF.

关 键 词：心房颤动 西地兰 胺碘酮 

分 类 号：R972[医药卫生—药品] R541.75[医药卫生—药学]