3种用药方案治疗胃溃疡的最小成本分析  

Cost-minimization Analysis of 3 Kinds of Regimens in the Treatment of Gastric Ulcer

作　　者：江启蓉[1] 王国俊[1] 杜国莲[1] 

机构地区：[1]泸州医学院附属医院药剂科,泸州市646000

出　　处：《中国药房》2010年第20期1906-1907,共2页China Pharmacy

摘　　要：目的:评价3种不同质子泵抑制剂治疗胃溃疡的疗效和经济学效果。方法:将134例患者按就诊时间分为A、B、C3组,分别给予奥美拉唑+阿莫西林+甲硝唑、雷贝拉唑+阿莫西林+甲硝唑、埃索美拉唑+阿莫西林+甲硝唑,采用最小成本分析法进行评价。结果:3组的痊愈率分别为85.42%、85.71%、86.36%(P>0.05);不良反应发生率分别为6.25%、4.76%、4.54%(P>0.05);药品成本分别为936.32、2011.52、1076.32元。结论:A组方案在临床疗效方面与B、C组无差异,但药品成本优于B、C组方案。OBJECTIVE：To evaluate the therapeutic efficacy and pharmacoeconomic results of 3 kinds of proton-pump inhibitors in the treatment of gastric ulcer.METHODS：134 patients with gastric ulcer were divided into 3 groups according to visiting time order.Group A were given omeprazole,amoxicillin and metronidazole and group B rabeprazole,amoxicillin and metronidazole,group C esomeprazole,amoxicillin metronidazole.Therapeutic efficacies of 3 groups were evaluated using cost minimization analysis.RESULTS：The cure rates of 3 groups were 85.42%,85.71% and 86.36 % respectively（P0.05）.The incidence of ADR were 6.25%,4.76% and 4.54% respectively（P0.05）.The costs of drug were 936.32,2 011.52 and 1 076.32 yuan respectively.CONCLUSION：Regimen of group A is same to other 2 groups in respect of therapeutic efficacy but better than them in cost of drugs.

关 键 词：质子泵抑制剂 胃溃疡 药物经济学 最小成本分析 

分 类 号：R917[医药卫生—药物分析学]