HLA-DQB1基因多态性与新疆汉族人群结核病易感性的研究  

Association of Polymorphism of HLA-DQB1 Gene with Susceptibility to Tuberculosis in Han Population in Xinjiang

作　　者：刘玉彩[1] 王喜[1] 贺鹏[1] 吴芳[1] 王萍[1] 章乐[1] 张万江[1] 

机构地区：[1]新疆石河子大学医学院,新疆石河子832002

出　　处：《现代生物医学进展》2010年第7期1232-1234,1293,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金资助项目(No30760237)

摘　　要：目的:探讨HLA-DQB1基因多态性与新疆汉族人群结核病发生发展的关联。方法:采用PCR-SSP技术对228例新疆塔城地区和石河子地区的肺结核患者及231例健康志愿者的HLA-DQB1的15个等位基因分型,比较各等位基因的频率(GF),并计算其优势比(OR)。结果:肺结核病例组DQB1*0201位点的基因频率显著高于对照组(Pc<0.05)其GF和OR分别为10.27%和1.947。结论:HLA-DQB1*0201可能是新疆地区汉族人群结核病发病的易感基因。Objectives：To investigate the association between the polymorphism of HLA-DQB1 gene and susceptibility to tuberculosis in Xinjiang Han population.Methods：228 patients with tuberculosis in Tacheng and Shihezi in Xinjiang were tested for the HLA-DQB1 gene using the polymerase chain reaction with sequence-specific primer（PCR-SSP）technique,and the results were compared with those of 231 healthy individuals.Results：The frequency of HLA-DQB1＊0201 in the group with tuberculosis disease is significantly higher than which in the group of control（Pc0.05,x2=18.76,Pc0.01,OR=3.90）.Conclusion：The results showed that HLA-DQB1＊0201 was probably susceptible gene in tuberculosis for Xinjiang Han population.

关 键 词：结核病 基因型 HLA-DQB1 PCR-SSP 

分 类 号：R52[医药卫生—内科学] Q75[医药卫生—临床医学]