树突状细胞及其Toll样受体与乙型肝炎慢性化研究进展  

Research progress on dendritic cells and Toll-like receptors and chronic mechanism of hepatitis B

作　　者：郭栋[1] 刘秋燕[1] 

机构地区：[1]第二军医大学免疫学研究所,上海200433

出　　处：《国际免疫学杂志》2010年第3期192-195,共4页International Journal of Immunology

摘　　要：目前认为，机体对乙型肝炎病毒（HBV）的免疫耐受是乙型肝炎慢性化的主要原因。作为最重要的抗原呈递细胞，树突状细胞（DC）无论数量不足还是功能缺陷都将导致HBV在体内的持续感染。Toll样受体（TLR）是当前免疫学研究的热点，近年来，人们逐渐认识到慢性乙型肝炎（CHB）患者体内Dc的TLR存在表达异常，这可能是导致乙型肝炎慢性化的一个重要原因。Body＇s immune tolerance to the hepatitis B virus is considered as the main reason of chronic Hepatitis B. Dendritic cells （DC） are the most potent professional antigen-presenting cells. The low quantity or functional defects of dendritic cells will result in persistent infection of hepatitis B virus in the body. Toll-like receptors （TLRs） is one of the immunology research hotspots in recent years. Studies have found that the abnor- mal expression of TLRs in patients of chronic hepatitis B may be an important reason for the persistent infection of hepatitis B virus.

关 键 词：树突状细胞 TOLL样受体 乙型肝炎 慢性化机制 

分 类 号：R51[医药卫生—内科学]