吡啶酰基芳酰氨基硫脲化合物的合成与杀菌活性  

Synthesis and fungicidal activities of thiourea derivatives containing pyridine moiety

作　　者：叶冬菊[1] 谢建伟[1] 章艺[1] 

机构地区：[1]衢州学院化学与制药工程系,浙江衢州324000

出　　处：《化学试剂》2010年第5期411-412,454,共3页Chemical Reagents

摘　　要：以烟酸为原料,通过酰氯化和硫脲化,合成了5个未见报道的酰胺基酰基硫脲衍生物。经核磁共振氢谱、质谱和元素分析确认了新化合物的结构。初步的生物活性测试结果表明,在500mg/L时N′-邻氟苯甲酰胺基-N-烟酰基硫脲和N′-对氯苯甲酰胺基-N-烟酰基硫脲对黄瓜褐斑病菌抑制率为94.36%和84.68%,N′-邻甲苯甲酰胺基-N-烟酰基硫脲对黄瓜曼枯病菌抑制率为58.16%。Five new thiourea derivatives containing pyridine moiety were synthesized and their structure were confirmed by 1HNMR,MS and elemental analysis.The preliminary bioassay indicated that N-（2-（2-fluorobenzoyl）hydrazinecarbonothioyl）nicotinamide and N-（2-（4-chlorobenzoyl）hydrazinecarbonothioyl）nicotinamide had good fungicidal activities against Corynespora cassiicola.N-（2-（2-methylbenzoyl）hydrazinecarbonothioyl）nicotinamide had moderate fungicidal activity against Ascochyta citrullina Smith.

关 键 词：烟酸 酰基硫脲 合成 杀菌活性 

分 类 号：TQ463[化学工程—制药化工] TQ455